Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep1134 | Late Breaking | ECE2023

An interplay between primary hyperparathyroidism, Hashimoto thyroidis and thyroid cancer

Sparavalo Rada , Borozan Sanja

The incidence of well differentiated thyroid carcinoma (TC), mostly papillary, is higher among patients with primary hyperparathyroidism (PHPT) compared to the general population, despite the similar frequency of thyroid nodules. The link between TC and Hashimoto thyroiditis (HT) is attributed to chronic inflammation, but the molecular association is poorly undestood. Herein, we explore the possible interplay between HT, PHPT and papillary TC through a case report and a litera...

ea0063p836 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

A germline ARMC5 mutation in a patient with adrenal adenoma and multiple colonic polyps: a case report

Sparavalo Rada , Borozan Sanja

Background: Functional studies demonstrate that Armadillo repeat-containing 5 (ARMC5) gene, controls apoptosis and steroid synthesis. A germline mutations in ARMC5 are recently been associated with Cushing syndrome and possibly can be responsible for a broader tumor predisposition.Case presentation: A 51-year-old woman presented with intermittent rectal bleeding. A colonoscopy revealed multiple colonic polyps, histopathological analysis showed tubular ad...

ea0049ep857 | Clinical case reports - Pituitary/Adrenal | ECE2017

Cushing’s disease management through time- a case report

Borozan Sanja , Boskovic Olivera

Cushing’s disease (CD) is a rare disorder caused by an increased secretion of adrenocorticotropin hormone (ACTH) from the anterior pituitary gland, usually as a result of pituitary adenoma. Transsphenoidal tumour resection is the best first line therapy option for these patients but 10–30% of them fail to achieve remission and need further treatment modalities to eliminate hypercortisolemia. Long-term outcomes and possible impacts on quality of life in these patients...

ea0070aep558 | General Endocrinology | ECE2020

Delay in diagnosis and clinical course of autoimmune polyglandular syndrome

Sparavalo Rada , Borozan Sanja

Autoimmune polyglandular syndromes (APS) are a rare group of autoimmune disorders that affect more than one endocrine gland, although non-endocrine organs can be involved. Concerning the variable evolution of this clinical entity over time, our case aims to emphasise the importance of regular follow-up and screening for polyglandular autoimmunity in selected patients in order to decrease a possibility of future complications consistent with APS. We report the case of a 20-year...

ea0070ep53 | Adrenal and Cardiovascular Endocrinology | ECE2020

Delayed diagnosis of Cushing’s syndrome

Sparavalo Rada , Borozan Sanja

Because of quite variable clinical manifestations of Cushing’s syndrome and overlap with more common medical problems, its diagnosis is frequently mistaken, with consequent considerable delay from the first presentation to a different primary and secondary care physicians to a final diagnosis, often made by endocrinologist. The diagnostic latency in reported studies vary from six months to ten years. We report a case of a 54-years-old female admitted to the hospital thro...

ea0070ep284 | Pituitary and Neuroendocrinology | ECE2020

Secondary amenorrhea and large uterine myomas in a patient with acromegaly

Borozan Sanja , Sparavalo Rada

Menstrual irregularity is common in women with acromegaly, occurring in 40–84% of patients. Its pathogenesis is still not well established although it is usually attributed to prolactin excess and/or gonadotropin deficiency. Also, since the presence of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) receptors is demonstrated in the myometrium, a pathogenetic role of GH in the development of myoma is examined through different studies. Moreover, some of them ...

ea0073aep442 | General Endocrinology | ECE2021

Corticosteroids – 70 years of balancing between good and bad

Borozan Sanja , Vujosevic Snezana

When in September 1948 the ’Compound E’ was first synthesized and successfully administered as intramuscular injection to a woman with rheumatoid arthritis, hardly that anyone could imagine what profound impact it will have on medical research and practice. In a span of just two years, in 1950, the fascinate drug was renamed to Cortisone and brought from laboratory to broad clinical use. Seventy years later, it is still hard to find a medical field where corticostero...

ea0073aep605 | Reproductive and Developmental Endocrinology | ECE2021

Primary amenorrhea due to hypogonadotropic hypogonadism

Sparavalo Rada , Borozan Sanja

A diagnosis of primary amenorrhea (PA) is always a clinical challenge. By definition, PA is a failure to reach menarche by age 14 with the absence of secondary sexual characteristics or absence of menses by age 16 years regardless of the development of secondary sexual characteristics. It may result from a number of different conditions and requires comprehensive evaluation to identify a cause, along with a regular patient follow-up. The aim of this case report is to emphasize...

ea0081ep468 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Painful fat necrosis as a consequence of insulin application - an unsolvable problem?

Borozan Sanja , Muzurovic Emir , Vujosevic Snezana

We report a case of 39–year-old female presented with painful, scaling skin lesions on insulin application sites. She was diagnosed with type 1 diabetes mellitus (T1DM) at the age of 21 years and treated with intensified conventional insulin therapy. Three months before hospital admission, she suddenly started to feel pain at insulin injection sites, followed by oval subcutaneous deposits and skin ulcer in the further course. Identical local changes repeated after subcuta...

ea0081ep1123 | Thyroid | ECE2022

Two types of thyroid cancer in one patient

Muzurovic Emir , Borozan Sanja , Vujosevic Snezana

A 65–year-old male was referred to endocrinologist due to significantly elevated calcitonin level of 3662 pg/ml. Previously, almost 3 decades before, the patient underwent right thyroid lobectomy for papillary carcinoma. Then, 9 years afterwards, he was reoperated and total thyroidectomy with neck exploration was performed. In pathohistological finding, metastatic papillary carcinoma was proved. Radioactive iodine ablation was used as a post surgical treatment. After comp...