Endocrine Abstracts

Forkhead box P3 (Foxp3) is an important regulatory factor for the development and function of T regulatory cells (Tregs). Moreover it has been established that deficiency of the Foxp3 gene in Treg cells suppresses their regulatory function leading to the development of autoimmune thyroid diseases (AITDs). The aim of our study was to estimate the association of three polymorphism of FOXP3 gene with the predisposition to GD and HT in children.<p class="abst...

Up till now, altered balance of T helper 1 (Th1) and Th2 immune cells has been postulated to play an important role in the pathogenesis of autoimmune thyroid diseases (AITD). However, recent studies on thyroid diseases suggest a new role for Th17 (T helper 17) cells which have the ability to secrete cytokines: IL17, IL17F, IL21, and IL23. The aim of the study was to estimate the proporcions of circulating CD4+CD161+CD196+ and CD4+IL17+ Th17 cells and serum concentrations of IL...