Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep818 | Late Breaking | ECE2021

Relevance of non-invasive central pressure measurements with vascular stiffness indicators to predict future cardiovascular risk in children with type 1 diabetes

Noiszewska Klaudyna , Bossowski Artur

IntroductionModern diabetology is focused on preventing late complications of diabetes and to find research tools to detect discrete changes, with the possibility of early entry with treatment. Type 1 diabetes (DM1) causes oxidative stress, affects the cardiovascular system and increases vascular stiffness. The non-invasive measurement of central blood pressure (CBP) together with augumentation and aplification indicators, more accurately reflects the co...

ea0073aep797 | Late Breaking | ECE2021

Effect of dexamethasone’s and triptorelin’s treatment in 9-year-old girl with congenital adrenal hyperplasia due to 21- hydroxylase deficiency- case report

Sawicka Beata , Hanna Borysewicz-Sanczyk , Bossowski Artur

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency is the most common disorder, in which lack of the enzyme causes deficiency aldosterone and cortisol. The result of this deficiency is an increased level of ACTH. The classic form appears in early childhood and may be associated with the development of abnormal genitalia. Clinically older patients present the GnRH-independent precocious puberty with rapid growth and advanced bone age. We present the case of 9-year-...

ea0049ep1226 | Paediatric endocrinology | ECE2017

Pediatric case of Autoimmune Polyglandular Syndrome type IIIC: autoimmune thyroid disease and severe autoimmune thrombocytopenia

Prokop Joanna , Leszczynska Elzbieta , Krawczuk-Rybak Maryna , Bossowski Artur

Introduction: Association between autoimmune thyroid disease (AITD) and other autoimmune disorders is common and known as autoimmune polyglandular syndrome (APS). It may involve hypoparathyoridism with Addison disease (AD) and mucocutaneous candidiasis – APS type I, AD with Diabetes mellitus type 1 (DM1) or AITD- APS type II, AITD associated with other autoimmune diseases (excluding AD): DM1- type IIIa, pernicious anemia- IIIb, or alopecia and/or vitiligo and/or other aut...

ea0016p823 | Thyroid | ECE2008

Analysis of selected adipocytokines in children with autoimmune thyroid diseases

Bossowski Artur , Sawicka Beata , Urban Miroslawa , Skrzydlo Marcin , Szalecki Mieczyslaw

Leptin, adiponectin and resistin play an essential role in regulation of body mass, which is controlled by thyroid hormones levels.The aim of the study was to evaluate leptin, adiponectin and resistin levels in young patients with Graves’ disease and in children with Hashimoto’s thyroiditis.The study group formed 78 patients suffering from Graves’ disease (30 girls and 2 boys; aged from 6 to 21- mean 15.2 years) and ...

ea0081p257 | Late-Breaking | ECE2022

Retrospective assessment of malignant thyroid nodules in a group of children and adolescents according to BTA U classification and ACR TI-RADS ultrasound-based risk stratification system in combination with elastography

Bossowski Artur , Borysewicz-Sanczyk Hanna , Sawicka Beata , Bossowski Filip , Karny Agata , Rusak Aleksandra , Dzieciol Janusz

The risk of malignancy in thyroid nodules correlates with the presence of ultrasound features. In adults, ultrasound risk-classification systems have been proposed to indicate the need for further invasive diagnosis. Furthermore, elastography has been shown to support differential diagnosis of thyroid nodules. The purpose of our study was to assess the application of the American Thyroid Association (ATA) and British Thyroid Association (BTA) ultrasound risk-classification sys...

ea0081p774 | Late-Breaking | ECE2022

Regulatory B cells involvement in autoimmune phenomena occurring in pediatric graves’ disease patients.

Bossowski Artur , Grubczak Kamil , Starosz Aleksandra , Stożek Karolina , Bossowski Filip , Moniuszko Marcin

Graves’s disease is the most common type of autoimmune hyperthyroidism. Numerous studies indicate different factors contributing to the onset of the disease. Despite years of research, the exact pathomechanism of Graves’ disease still remains unresolved, especially in the context of immune response. B cells can play a dual role in autoimmune reactions, on the one hand, as a source of autoantibody mainly targeted in the thyroid hormone receptor (TSHR) and, on the othe...

ea0066oc2.2 | Oral Communications 2 | BSPED2019

A rare but very important cause of growth failure

Cottrell Emily , Ladha Tasneem , Borysewicz-Sańczyk Hanna , Sawicka Beata , Bossowski Artur , Storr Helen L

Introduction: Bloom syndrome (BS) is a rare autosomal recessive disorder caused by mutations in the BLM gene. Classic dysmorphic features include a long, narrow face, micrognathism and prominent nose and ears. Other features of the disease include pre- and post-natal growth failure, skin rash following sun exposure, hyper-pigmented areas or cafe-au-lait lesions, high-pitched voice and immunodeficiency. The most serious complication of BS is the significant increase in...

ea0035p818 | Paediatric endocrinology | ECE2014

Analysis of Th17 cells and IL17, IL23 cytokines in peripheral blood from children with autoimmune thyroid disease

Bossowski Artur , Moniuszko Marcin , Dabrowska Milena , Jeznach Marta , Rusak Malgorzata , Bossowska Anna

Up till now, altered balance of T helper 1 (Th1) and Th2 immune cells has been postulated to play an important role in the pathogenesis of autoimmune thyroid diseases (AITD). However, recent studies on thyroid diseases suggest a new role for Th17 (T helper 17) cells which have the ability to secrete cytokines: IL17, IL17F, IL21, and IL23. The aim of the study was to estimate the proporcions of circulating CD4+CD161+CD196+ and CD4+IL17+ Th17 cells and serum concentrations of IL...

ea0016p687 | Thyroid | ECE2008

Expression of RNA-binding proteins TIAR and TIA-1 in thyroid tissues from patients with immune and non-immune thyroid diseases

Bossowski Artur , Czarnocka Barbara , Bardadin Krzysztof , Urban Miroslawa , Czerwinska Jolanta , Lyczkowska Anna , Dadan Jacek

TIAR and TIA-1 are two closely related RNA-binding proteins, which possess three RNA recognition motifs (RMMs). These proteins are involved in several mechanisms of RNA metabolism, including regulation of mRNA translation. In cellular apoptosis continuously TIAR shuttled between the cytoplasm and nucleus.The aim of this study was to estimate expression of closely related mRNA binding proteins TIAR and TIA-1 in thyroid tissues from young patients with Gra...

ea0073aep892 | Late Breaking | ECE2021

Evaluating the role of circulating dendritic cells in methimazole-treated pediatric Graves’ disease patients

Starosz Aleksandra , Karolina Stoɫek , Moniuszko Marcin , Grubczak Kamil , Bossowski Artur

Graves’ disease (GD) is hyperthyroidism associated with organ-specific autoimmune 14 inflammation. GD occurs more frequently in adults than in children, however, pediatric patients are 15 a therapeutic challenge due to cycles of remissions and relapses requiring constant monitoring at 16 every stage of treatment administered. Dendritic cells (DCs) are considered a link between innate 17 and adaptive immunity. DCs as antigen-presenting cells (APCs) are involved in antigen ...