Searchable abstracts of presentations at key conferences in endocrinology

ea0034p330 | Reproduction | SFEBES2014

Transforming growth factor-β superfamily signalling and its role in the pathogenesis of heavy menstrual bleeding

Maybin Jacqueline , Boswell Lyndsey , Duncan Colin , Critchley Hilary

Introduction: The human endometrium has a remarkable capacity for repeated repair following the inflammation of menstruation. This occurs without scarring or loss of function but mechanisms involved remain undefined. Aberrations in endometrial repair may lead to pathology such as heavy menstrual bleeding (HMB). The transforming growth factor-β superfamily has been implicated in efficient wound repair and has a potential role in menstrual repair. Downstream of TGF-β, ...

ea0035p683 | Growth hormone IGF axis basic | ECE2014

The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome

Siemienowicz Katarzyna , Boswell Lyndsey , Carr David , Mina Theresia , Connolly Fiona , Rae Mick , Duncan Colin

Exposure of pregnant sheep to increased concentrations of testosterone during midgestation results in a PCOS-like condition in the female offspring that includes increased hepatic IGF1. The aim of this study was to investigate the molecular pathophysiology of this increase. We studied 11-month-old female offspring whose mother had been treated with testosterone propionate (TP: 100 mg) in oil (n=8), or oil control (n=4) twice weekly from day 62 to 102 gestatio...