Searchable abstracts of presentations at key conferences in endocrinology

ea0073oc14.6 | Oral Communications 14: Across Endocrinology | ECE2021

Endocrine disorders in patients with Fabry Disease: A comprehensive reference center study

Bothou Christina , Beuschlein Felix , Nowak Albina

Fabry Disease (FD) is a rare X–linked metabolic storage disease characterized by a–galactosidase A deficiency and deficient lysosomal function. The patients suffer from diffuse organ manifestations due to the accumulation of the substrate globotriaosylceramide (Gb3), which are only partially reversed by the available enzyme replacement (ERT) therapies. Previous endocrinological studies in patients with FD included small patient numbers or focused on a certain organ...

ea0081p232 | Thyroid | ECE2022

Levothyroxine Replacement Therapy overuse. Factors suggesting treatment discontinuation

Livadas Sarantis , Bothou Christina , Paparodis Rodis , Androulakis Ioannis , Angelopoulos Nicholas , Boniakos Anastasios , Anagnostis Panagiotis , Duntas Leonidas

Background: Levothyroxine (LT4-Rx) is one of the most prescribed drugs worldwide and the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects we found that 60% of this cohort were euthyroid two months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98...

ea0049oc4.5 | Thyroid Disease 1 | ECE2017

Levothyroxine replacement therapy: once treatment is started, should it last indefinitely?

Livadas Sarantis , Bothou Christina , Androulakis Ioannis , Boniakos Anastasios , Angelopoulos Nicholas , Duntas Leonidas

Background: Levothyroxine (LT4) is one of the most prescribed drugs worldwide. Once started, about 90% of patients continue LT4 treatment long-term.Aim of the study: To evaluate the necessity of long-term thyroxine supplementation and to determine the prognostic factors that could identify which patients may discontinue LT4 treatment.Design and methods: LT4 replacement therapy was paused for at least six weeks in all patients conse...

ea0056p918 | Female Reproduction | ECE2018

Young lean women with evidence of both premature adrenarche and pubarche display a metabolic, hormonal and psychologic profile that is similar to that of their peers with polycystic ovary syndrome

Livadas Sarantis , Bothou Christina , Kanaka-Gantenbein Christina , Chiotis Dimitrios , Angelopoulos Nicholas , Macut Djuro , Chrousos George P.

Context: The early activation of adrenal zona reticularis, denoted by increased circulating levels of adrenal androgens before the age of eight years in girls is called premature adrenarche (PA), while the concomitant appearance of pubic hair is termed premature pubarche (PP). Girls with PA-PP display an unfavorable metabolic, hormonal and psychologic profile, compared to their normal peers and are also at an increased risk of developing polycystic ovary syndrome (PCO...

ea0073aep225 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The effect of obesity on the association between type 2 diabetes mellitus and polycystic ovary syndrome: a meta-analysis of observational studies

Anagnostis Panagiotis , Paparodis Rodis , Bosdou Julia , Bothou Christina , Macut Djuro P. , Goulis Dimitrios , Livadas Sarantis

ObjectiveThe exact risk of type 2 diabetes in women with polycystic ovary syndrome (PCOS) is unknown. It is also unclear if obesity independently increases the risk in this population. The aim of this study was to systematically review and synthesize the best available evidence regarding the association between PCOS and type 2 diabetes, stratified according to obesity status.MethodsA comprehensive search was ...

ea0081yi12 | Young Investigator Awards | ECE2022

Role of the transcription factor HHEX in inner adrenal cortex homeostasis and response to progesterone signaling

Dumontet Typhanie , Basham Kaitlin , Lerario Antonio , Bothou Christina , Brixius Bjoern , Turcu Adina F , Beuschlein Felix , Hammer Gary D

The adrenal glands serve as central organs of the endocrine system by producing steroid hormone essential for organismal homeostasis. Mechanisms ensuring proper adrenal homeostasis and function are therefore crucial for maintaining human life. ACTH, released by the pituitary corticotrope, is required for the differentiation of the inner part of the adrenal cortex (the zona fasciculata) and the resultant stimulation of cortisol production. Perturbation of ACTH signaling can lea...

ea0063p297 | Reproductive Endocrinology 1 | ECE2019

The natural course of normal weight women with polycystic ovary syndrome: an insight into metabolic changes of a large Caucasian cohort

Livadas Sarantis , Macut Djuro , Bothou Christina , Kuliczkowska-Płaksej Justyna , Vryonidou Andromahi , Bjekic-Macut Jelica , Mouslech Zadalla , Milewicz Andrzej , Panidis Dimitrios

Objective: Polycystic ovary syndrome (PCOS) is hypothesized to originate in foetal life, while its long-term consequences extend beyond menopause. However, the natural course of the disorder has not as yet been elucidated, and recent data suggest differences in the evolution of PCOS according to a woman’s weight. We aimed to define the evolution of normal-weight Caucasian women with PCOS through the years.Design: Cross-sectional case control study</...

ea0070aep821 | Reproductive and Developmental Endocrinology | ECE2020

Prevalence and prognostic factors of dysglycemia in women with polycystic ovary syndrome: Findings from large caucasian cohort

Livadas Sarantis , Bothou Christina , Kuliczkowska-Płaksej Justyna , Robeva Ralitsa , Vryonidou Andromahi , Bjekic Macut Jelica , Androulakis Ioannis , Mouslech Zadalla , Milewicz Andrej , Panidis Dimitrios , Macut Djuro

Background: Insulin secretory defects and insulin resistance exists in women with polycystic ovary syndrome (PCOS) and are prerequisites for the development of type 2 diabetes (T2D). we aimed to determine the prevalence of T2D, impaired glucose tolerance (IGT) and impaired fasting glucose (IFG), as well as the factors associated with these dysglycemic conditions in this population.Methods: 1614 PCOS women of Caucasian origin (Rotterdam criteria) with a m...

ea0073oc11.2 | Oral Communications 11: Adrenal and Cardiovascular Endocrinoloyg | ECE2021

Extensive preclinical screening of chemotherapeutic agents and molecular targeted Inhibitors reveals potent combinatory treatment for adrenocortical carcinoma (ACC)

Bothou Christina , Sharma Ashish , Shapiro Igor , Adrian Oo , Kim Baek , Beuschlein Felix , Perge Pal , Igaz Peter , Ronchi Cristina L. , Hantel Constanze

Current systemic treatment options for patients with ACCs are far from being satisfactory. DNA damage/repair mechanisms, which involve e.g. ATM/ATR-signalling or RRM1/RRM2 encoded ribonucleotide reductase (RNR) activation commonly contribute to drug resistance. Moreover, also the regulation of RRM2b, the p53-induced alternative to RRM2, is of unclear importance for ACC. Upon extensive drug screening, including a large panel of classical chemotherapies (doxorubicin, etoposide, ...

ea0063gp190 | Adrenal and Neuroendocrine - Clinical | ECE2019

Management and outcome of pregnancies in women with adrenal insufficiency: experience from a retrospective European study

Bothou Christina , Anand Gurpreet , Kienitz Tina , Seejore Khyatisha , Simeoli Chiara , Ward Emma G , Paragliola Rosa Maria , Ferrigno Rosario , Badenhoop Klaus , Bensing Sophie , Oksnes Marianne , Drake William , Wahlberg Jeanette , Reisch Nicole , Hahner Stefanie , Pearce Simon , Trainer Peter , Etzrodt-Walter Gwendolin , Thalmann Sebastien P , Saevik AEse B , Husebye Eystein , Isidori Andrea M , Falhammar Henrik , Meyer Gesine , Corsello Salvatore M , Pivonello Rosario , Murray Robert , Quinkler Marcus , Beuschlein Felix

Background and aims: Recommendations for the management of pregnancies in patients with adrenal insufficiency (AI) are scarce. The aim of this study was to analyse current clinical approaches in seventeen specialized centers across Europe with a particular focus on maternal and fetal outcome.Patients: 95 pregnancies in 86 patients with AI of different aetiology [Addison’s disease (n=37), secondary AI (n=22), congenital adrenal hype...