ea0014oc5.2 | Thyroid basic | ECE2007
Lisi Simonetta
, Botta Roberta
, Pinchera Aldo
, Marcocci Claudio
, Marinò Michele
RAP KO mice have a reduction of colloidal Tg resulting in subclinical hypothyroidism and histological signs of goiter. The difference in colloidal Tg between RAP KO and WT mice was striking by immunohistochemistry, but could not be detected in thyroid extracts. To explain this discrepancy, we hypothesized that the reduction of Tg reflected a reduction of Tg aggregates discarded during tissue extraction. To investigate this possibility, pellets obtained by thyroid homogenizatio...