Searchable abstracts of presentations at key conferences in endocrinology

ea0029p907 | Female Reproduction | ICEECE2012

Association of the (TAAAA)n repeat polymorphism of SHBG gene with age at menopause in Greek postmenopausal women

Markatseli A. , Hatzi E. , Bouba I. , Xita N. , Tigas S. , Georgiou I. , Tsatsoulis A.

Introduction: Sex hormone-binding globulin (SHBG) regulates the bioavailability of sex steroid hormones, which in turn regulate reproductive function. The potential association of SHBG gene polymorphisms with the age at menopause has not been examined.Objective: The present study aimed to assess the possible relationship between the pentanucleotide (TAAAA)n repeat polymorphism in the promoter of the SHBG gene and the age at menopause in a Greek fe...

ea0026p524 | Bone/calcium/Vitamin D | ECE2011

Association of the A1330V and V667M polymorphisms of LRP5 with bone mineral density in Greek peri- and postmenopausal women

Markatseli A , Hatzi E , Bouba I , Georgiou I , Challa A , Tigas S , Tsatsoulis A

Wnt signaling through low-density lipoprotein receptor-related protein 5 (LRP5) is an important determinant of bone mass regulation. Polymorphisms in the LRP5 gene have been associated with either osteoporotic phenotypes or normal bone mineral density (BMD) variation.Objective: To explore the influence of two LRP5 single nucleotide polymorphisms (SNPs) A1330V and V667M on BMD and serum levels of osteoprotegerin (OPG), receptor activator of nuclear factor...