Endocrine Abstracts

Introduction: The development of colorectal cancer is influenced by dietary as well as growth factors. Butyrate, (NaB) one of the metabolic by-products of bacterial fermentation of dietary fibre is a primary source of energy for colonic mucosa. It has growth-promoting effects on normal colonic epithelial cells, induces cell cycle arrest, differentiation and apoptosis in colorectal cancer cells. Since it has been suggested that the apoptotic effects of NaB may be due to its syn...