Searchable abstracts of presentations at key conferences in endocrinology

ea0011p765 | Steroids | ECE2006

NaB affect the local regulation of vitamin D in colorectal cancer

Ogunkolade BW , Khalaf S , Boucher BJ , Davis D , Dorudi S , Jenkins PJ , Bustin SA

Introduction: The development of colorectal cancer is influenced by dietary as well as growth factors. Butyrate, (NaB) one of the metabolic by-products of bacterial fermentation of dietary fibre is a primary source of energy for colonic mucosa. It has growth-promoting effects on normal colonic epithelial cells, induces cell cycle arrest, differentiation and apoptosis in colorectal cancer cells. Since it has been suggested that the apoptotic effects of NaB may be due to its syn...