Searchable abstracts of presentations at key conferences in endocrinology

ea0077p79 | Neuroendocrinology and Pituitary | SFEBES2021

MRI bone shape in patients with acromegaly: a novel technique for the characterisation of the acromegalic arthropathy

Kyriakakis Nikolaos , Bowes Michael , Lynch Julie , Kingsbury Sarah , Orme Steve , Murray Robert , Conaghan Philip

Objective: Arthropathy is the commonest morbidity in acromegaly and the main determinant of quality of life in these patients. Most of current knowledge is derived from studies using conventional x-rays. This study aims to characterise acromegalic arthropathy using modern imaging techniques.Methods: Case control study comprising of 60 acromegaly patients (29 males, mean age 54.8± 12.9yrs) and 300 age/gender-matched controls from the publicly availab...

ea0081rc4.3 | Rapid Communications 4: Pituitary and Neuroendocrinology 1 | ECE2022

Pre-treatment GH levels and number of therapeutic interventions for acromegaly management are predictive of altered MRI bone shape and severity of arthropathy in acromegaly

Kyriakakis Nikolaos , Bowes Michael , Lynch Julie , Kingsbury Sarah R , M Orme Steve , Murray Robert D , Conaghan Philip G

Introduction: Emerging research in 3D-bone shape has provided new insights into the pathogenesis of osteoarthritis (OA). OA patients have increased subchondral bone area, associated with higher prevalence of cartilage loss. Higher B-score, a novel, machine learning-derived OA bone biomarker, is associated with increased OA symptom severity and structural progression. Arthropathy, despite being the commonest cause of morbidity amongst acromegaly patients, remains one of the und...