Searchable abstracts of presentations at key conferences in endocrinology

ea0025p314 | Thyroid | SFEBES2011

Carbimazole embryopathy: implications for the choice of antithyroid drugs in pregnancy

Bowman Pamela , Osborne Nigel , Sturley Rachel , Vaidya Bijay

Background: Maternal thyrotoxicosis affects 0.2% of pregnancies. Pharmacological treatments include carbimazole, methimazole and propylthiouracil. The Endocrine Society recommends the use of propylthiouracil as first line during pregnancy, because of possible associations between carbimazole and congenital anomalies. However, recent reports link propylthiouracil to liver injury in adults, children, pregnant women and fetuses, raising questions over its safety.<p class="abs...