Searchable abstracts of presentations at key conferences in endocrinology

ea0090rc8.4 | Rapid Communications 8: Calcium and Bone | ECE2023

Encaleret (CLTX-305) normalized mineral homeostasis parameters in patients with autosomal dominant hypocalcemia type 1: Results over 12 months in a phase 2 study (NCT04581629)

Collins Michael , Hartley Iris , Roszko Kelly , Nemeth Edward , Pozo Karen , Boykin Winsome , Mathew Arun , Roberts Mary Scott , Adler Scott

Autosomal dominant hypocalcemia type 1 (ADH1), caused by gain-of-function calcium-sensing receptor gene (CASR) variants, is characterized by low parathyroid hormone (PTH) levels, hypocalcemia, hypercalciuria, hyperphosphatemia and hypomagnesemia. Conventional therapy (calcium and active vitamin D) worsens hypercalciuria, which may result in renal complications. Calcilytics, such as encaleret, are negative allosteric modulators of the calcium-sensing receptor (CaSR). T...