Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep1219 | Late Breaking | ECE2022

Thyrotoxicosis after the cessation of amiodarone treatment

Bozic-Antic Ivana

Introduction: Amiodarone is an effective drug for treating heart arrhythmias. High iodine content and specific metabolism of this drug, in 15-20% of patients lead to thyroid function disorder. Amiodarone induced thyrotoxicosis (AIT type 1 or type 2) usually occurs during the use of the drug, while it is rare after the drug cessation.The aim: A case report of a patient with type 2 AIT that manifested after the cessation of short-term amiodarone treatment....

ea0063p567 | Diabetes, Obesity and Metabolism 2 | ECE2019

Cardiovascular risk in obese women with polycystic ovary syndrome using Framingham scoring system

Ilic Dusan , Bozic Antic Ivana , Popovic Bojana , Bogavac Tamara , Isailovic Tatjana , Elezovic Kovacevic Valentina , Ognjanovic Sanja , Macut Djuro

Objectives: Women with polycystic ovary syndrome (PCOS) are at increased risk for cardiovascular disease. Aim of our study was to determine the frequency of cardiovascular risk factors using Framingham Scoring system (FSS) in PCOS and controls.Methods: FFS included age, value of cholesterol and HDL (mmol/L), smoking and systolic blood pressure (sysBP, mmHg). We also determined LDL (mmol/l), oxidized LDL (OxLDL, U/l) and triglycerides (mmol/l). We studied...

ea0049gp140 | Female Reproduction | ECE2017

Nonalcoholic fatty liver disease liver fat score (NAFLD-LFS) could be used for the assessment of NAFLD in women with PCOS

Bjekic-Macut Jelica , Bozic-Antic Ivana , Tziomalos Konstantinos , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Macut Djuro

Introduction: A relation between polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD) was demonstrated recently. Both NAFLD and PCOS are associated with increased risk for type 2 diabetes and cardiovascular disease. NAFLD liver fat score (NAFLD-LFS) has been implicated as a non-invasive surrogate marker for NAFLD. The aim of this study was to identify the prevalence of NAFLD in different PCOS phenotypes using NAFLD-LFS.Methods: W...

ea0044p213 | Reproduction | SFEBES2016

The relation of liver enzymes and insulin resistance in women with polycystic ovary syndrome (PCOS)

Macut Djuro , Bozic-Antic Ivana , Tziomalos Konstantinos , Bjekic-Macut Jelica , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Panidis Dimitrios

Introduction: There is a link between polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD). Here, we analyzed transaminazes and their relation to insulin resistance (IR) in PCOS women.Methods: We analyzed 600 women with PCOS diagnosed using ESHRE/ASRM criteria (age:25.6±5.9 years, BMI: 30.6±6.9 kg/m2), and 125 BMI-matched healthy controls (age: 31.4±5.3 years, BMI: 29.6±6.8 kg/m2). IR was...

ea0041gp20 | Adrenal (1) | ECE2016

Responsiveness to hCG in postmenopausal women with adrenal adenomas

Popovic Bojana , Macut Djuro , Bozic-Antic Ivana , Bogavac Tamara , Ilic Dusan , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Damjanovic Svetozar

Introduction: Luteinizning hormone (LH/hCG) responsiveness has been documented in both normal and pathological adrenal glands, but it is unclear whether chronic exposure to LH could affect adrenal function by increasing LH receptor (LHR) expression.Subjects and methods: We studied 12 postmenopausal women with previously documented adrenal tumor. All patients underwent standard hormonal testing for assessment of tumor functionality. Then hCG test was perf...

ea0041ep631 | Endocrine tumours and neoplasia | ECE2016

Clinical characteristics, survival and prognostic factors of patients with adrenocortical carcinoma: a tertiary centre experience

Elezovic Valentina , Macut Djuro , Ognjanovic Sanja , Isailovic Tatjana , Popovic Bojana , Bozic Antic Ivana , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

Adrenocortical carcinoma (ACC) is rare malignancy associated with poor prognosis. The aim of this study was to present clinical characteristics and survival of patients with ACC and to analyse the effect of prognostic factors on survival.We retrospectively analysed 69 patients (46 female and 23 males) with pathologically confirmed ACC who were treated in our hospital between January 2005 and December 2015. The median age at diagnosis was 51,0 years (rang...

ea0070aep655 | Endocrine-related Cancer | ECE2020

Correlation of chromogranin a and standard metabolic parameters in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

Bozic-Antic Ivana , Ognjanovic Sanja , Popovic Bojana , Isailovic Tatjana , Bogavac Tamara , Ilic Dusan , Elezovic-Kovacevic Valentina , Macut Djuro

Introduction: Chromogranin A (CgA) is a major representative of the protein family named granins stored predominately in secretory granules of the diffuse neuroendocrine system. Circulating CgA serves as a biomarker of neuroendocrine tumors (NETs), but its increased plasma concentration is present in various cardiovascular, gastrointestinal, renal and inflammatory diseases. Intra-granular and/or extracellular proteolysis of CgA generates a variety of biologically active fragme...

ea0056p949 | Female Reproduction | ECE2018

Association of hormonal and metabolic status with carotid intima-media thickness in women with polycystic ovary syndrome

Bjekic-Macut Jelica , Bozic-Antic Ivana , Erceg Snjezana , Civcic Milorad , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Macut Djuro

Introduction: Women with polycystic ovary syndrome (PCOS) have numerous risk factors that lead to higher risk for cardiovascular diseases (CVD) and stroke. Measurement of carotid intima-media thickness (CIMT) is a marker of CVD.Methods: We analyzed 399 women with PCOS diagnosed using ESHRE/ASRM criteria (age: 25.5±5.1 years, BMI: 24.9±6.2 kg/m2), and 82 BMI-matched healthy controls (age 29.2±5.9 years, BMI 25.3±8.6 kg/m<sup...

ea0063p662 | Interdisciplinary Endocrinology 1 | ECE2019

Adaptation of hypothalamo-pituitary-adrenal axis and cardio-metabolic parameters to physical stress in professional athletes

Popovic Bojana , Macut Djuro , Popovic Dejana , Banovic Marko , Bozic Antic Ivana , Isailovic Tatjana , Ognjanovic Sanja , Bogavac Tamara , Elezovic Kovacevic Valentina , Ilic Dusan , Damjanovic Svetozar

Introduction: Although intensive, repeated and perennial, physical stress of training generally does not represent a health hazard to professional athletes. Adaptation to such stress is presumed on multiple levels, but still not fully defined. Our aim was to analyze specificities of hypothalamic-pituitary-adrenal (HPA) axis response and adaptation to physical stress in professional athletes.Subjects and methods: We exposed 55 professional male athletes t...

ea0063p1130 | Reproductive Endocrinology 2 | ECE2019

The metabolic effects of metformin, cyproterone-acetate and their combination in women with polycystic ovary syndrome

Bozic-Antic Ivana , Ilic Dusan , Bogavac Tamara , Erceg Snjezana , Lacmanovic Mirjana , Popovic Bojana , Isailovic Tatjana , Elezovic-Kovacevic Valentina , Ognjanovic Sanja , Vojnovic-Milutinovic Danijela , Macut Djuro

Introduction: Metformin and oral contraceptive pills (OCP) are the most commonly prescribed medications among women with polycystic ovary syndrome (PCOS). The aim of this study was to compare effects of pill containing cyproterone-acetate (CPA) and metformin (METF) in women with PCOS during six months of follow-up.Methods: Group of 60 women with PCOS diagnosed by ESHRE/ASRM criteria were divided into 3 subgroups (20 women each), which were treated with d...