Searchable abstracts of presentations at key conferences in endocrinology

ea0028cmw1.4 | The late consequences of cancer therapy in adults | SFEBES2012

The late consequences of cancer therapy to the thyroid

Brabant Georg

Endocrine late effects following cancer therapy are increasingly recognized. Due to the radio-sensitivity of the thyroid gland both long-term effects on thyroid function and growth have been described. This includes problems of thyroid growth and function. Particularly the development of secondary neoplasms of the thyroid is greatly increased some 10 to 30 years following irradiation. This affects predominantly children before and during puberty. The longitudinal use of thyroi...

ea0016s27.4 | Nodules and more: new aspects of thyroid disorders | ECE2008

Nodules and more

Brabant Georg

The pathophysiology of thyroid nodules is still widely undefined even though recent data from microarray studies hint towards a distinct group of candidate genes. Furthermore, a better understanding of new mechanisms involved in thyroid growth regulation like TGF-β, BMP and wnt signalling may open new avenues for treatment. Recent data derived from animal models of thyroid carcinomas suggest an action of thyroid hormones despite the loss of TSH receptor. Upon confirmation...

ea0037mte4 | (1) | ECE2015

Management of thyroid eye disease

Brabant Georg , Eckstein Anja

The diagnosis of TED is not always obvious and its management can be a challenging. Diagnosis as well as treatment should be performed in a multidisciplinary setting. Decision on treatment is based on a careful assessment of ophthalmological symptoms and the evaluation of the clinical activity of the disease using the clinical activity score. TED is classified into mild, moderate and sight threatening disease. An active inflammatory disease stage is followed by an inactive sta...

ea0021p290 | Pituitary | SFEBES2009

Adult GH replacement and risk of tumour recurrence: 15 years experience from a large single centre

Mackenzie Scott , Brabant Georg

GH replacement (GHR) has resulted in a significant improvement in quality of life for many adults with GH deficiency. Many of these patients are previously irradiated survivors of malignancy, and as such are at high risk of recurrent (RN) or secondary neoplasms (SN). There is a particularly strong association between CNS irradiation and subsequent development of meningiomas, which are known to express GH receptors. There is uncertainty as to whether GHR increases the risk of d...

ea0025p246 | Pituitary | SFEBES2011

SIADH of cancer: rapid diagnostic evaluation using copeptin as a marker of AVP

Dixit Kashinath , Morgenthaler Nils , Brabant Georg

With the advent of vaptans as a therapeutic option, rapid and precise diagnosis of SIADH is essential. SIADH due to paraneoplastic stimulation of AVP is an expected but not the only cause of hyponatraemia in cancer patients. Therefore a precise evaluation of the cause of hyponatraemia is necessary before any therapeutic approach. Using Copeptin, a stable marker of AVP, which is stoichiometrically released with AVP, we evaluated 49 patients with hyponatremia due to various form...

ea0022oc3.2 | Pituitary | ECE2010

Copeptin, an arginine vasopressin (AVP) marker, as a diagnostic aid in SIADH of cancer

Dixit Kashinath , Morgenthaler Nils , Brabant Georg

Copeptin is a stable AVP marker and stoichiometrically released with AVP. It closely reflects changes in water balance. Its stimulation in severe stress has recently has been suggested in various pathophysiological conditions including myocardial infarction and stroke. Paraneoplastic stimulation of AVP/copeptin is expected in patients with cancer leading to hyponatraemia due to SIADH.Here, we evaluated copeptin levels in 50 patients with hyponatraemia du...

ea0041ep830 | Obesity | ECE2016

Identification of adipogenesis specific microRNAs

Lisa Cherradi M. , Perwitz Nina , Werner Ralf , Brabant Georg E.

Introduction: Obesity associated with the risks of metabolic syndrome is a rising problem in Western societies but shows a wide depot- and sex-specific variation. A better understanding of the regulatory mechanisms underlying this different depot- and sex-specific role is crucial to identify potential diagnostic and therapeutic targets. MicroRNAs are recently recognized important players in adipogenesis and fat metabolism. They post-transcriptionally regulate diverse biologica...

ea0037ep1118 | Endocrine tumours | ECE2015

Oestrogen- and progesterone-receptors may play a role in the pathogenesis of gastroenteropancreatic neuroendocrine tumours

Zimmermann Nadine , Brabant Georg , Begum Nehara , Thorns Christoph

A positive expression of oestrogen-receptors has recently been demonstrated in pancreatic neuroendocrine tumours as well as in non-neoplastic islet-cells. This prompted us to systematically analyse the expression of both oestrogen and progesterone receptors in a series of GEP neuroendocrine tumours. We analysed oestrogen- and progesterone-receptor in 69 foregut GEP, 25 midgut GEP and seven hindgut GEP. Namely, the foregut GEP included 53 pancreatic NET. All tumour samples were...

ea0028p339 | Thyroid | SFEBES2012

The PI3K and HIF pathways promote radio-resistance in thyroid-carcinoma

Burrows Natalie , Williams Joseph , Brabant Georg , Williams Kaye

Background: Anaplastic thyroid-carcinomas (ATC) and a subset of papillary (PTC) and follicular (FTC) thyroid carcinomas behave aggressively showing metastatic spread and radio-resistance. Both the PI3K and HIF pathways are associated with aggressiveness and metastasis in thyroid carcinoma.Aims: To assess if the PI3K/HIF pathways contribute to radio-resistance and assess the effect of PI3K/HIF inhibition on radio-sensitivity and metastatic behaviour of th...

ea0025p208 | Growth and development | SFEBES2011

The use of a novel injection delivery system to address compliance in patients receiving GH replacement therapy

McGlynn Stephen , Edwards Michael , Smethurt Linda , Brabant Georg

The majority of adult GH replaced patients reach target IGF1 levels using established injection devices. However, a small but significant cohort of these patients fail to achieve these intended goals. This can be manifested as either a failure to improve (biochemically or symptomatically) despite escalating GH doses, or large variations in IGF1 measurements despite steady GH dosing.The Easypod® device has a memory chip which allows record...