Searchable abstracts of presentations at key conferences in endocrinology

ea0010p7 | Clinical case reports/Governance | SFE2005

A rare cause of hypokalaemia

Brackenridge A , Bano G , Nussey S

A 26 year old lady presented to her general practitioner complaining of fatigue. Investigations showed serum potassium of 2.5 mmol/l, (reference range 3.3–4.7 mmol/l). This was repeated on two more occasions and was 2.6 and 2.8 mmol/l. An ECG showed no features of hypokalaemia. She was seen in Endocrine clinic with serum potassium of 2.5 mmol/l. There was no history of an eating disorder, laxative or diuretic abuse. Her father had type 2 diabetes. Her height was 1.56 m a...

ea0005p55 | Clinical Case Reports | BES2003

Growth hormone deficiency and pregnancy

Brackenridge A , Breen L , Russell-Jones D

It is recognised that growth hormone deficiency causes disturbances in reproductive function. Indeed growth hormone has been used for ovulation induction in the treatment of subfertility in women with hypopituitarism. During normal pregnancy growth hormone is produced by the placenta (placental growth hormone). From 15 to 20 weeks gestation placental growth hormone gradually replaces pituitary growth hormone in the maternal circulation and is the main determinant of maternal I...

ea0063p543 | Diabetes, Obesity and Metabolism 2 | ECE2019

Exploratory study into communication styles of diabetes healthcare professionals according to their patients numerical ability

Menon Vaishnavi , Harris Sophie , Brackenridge Anna , Amiel Stephanie

Background and aims: Type 1 diabetes mellitus (T1DM) requires daily self-management to mimic endocrine function, using numerical skills such as carbohydrate counting and interpreting nutritional information. Healthcare professionals (HCPs) rely on effective communication to relay information to people with T1DM to enable good self-care. Curricula for diabetes self-management education (DSME) courses require high-school level numerical skills. Eighty percent of adults in the Un...

ea0035p377 | Diabetes (epidemiology, pathophysiology) | ECE2014

Assessment of relaxin levels in pregnant women with gestational diabetes mellitus

Zaman Iftikhar , Swaminathan Ramasamyiyer , Brackenridge Anna , Sankaralingam Arun , McGowan Barbara

Introduction: Gestational diabetes mellitus (GDM) is an important co-morbidity of pregnancy, with insulin resistance a key contributor in its underlying pathology. Relaxin is a hormone considered crucial for mediating adaptations deemed vital for maintenance of pregnancy. Evidence has suggested that levels of plasma relaxin may be positively correlated with insulin sensitivity. This led us to hypothesize that relaxin may play a role in the pathogenesis of insulin resistance in...

ea0015p88 | Clinical practice/governance and case reports | SFEBES2008

Experience from the first two years of a dedicated clinic for adults with Turner syndrome

Doherty Emma , Powrie Jake , Thomas Stephen , Brackenridge Anna , Carroll Paul

Recently updated international guidelines recommend specialist surveillance of adults with Turner Syndrome (TS). In 2005, we established a dedicated TS clinic, attracting referrals from our general endocrine service and other specialities including primary care.Twenty-three patients currently attend of whom 9 were previously under endocrinology review. Karyotypes include 45XO (8/23), 45XO/46XrX (4/23), and 45XO/46XiXq (3/23). Mean (±S.D.</sma...

ea0055p18 | Poster Presentations | SFEEU2018

Type 1 diabetes presenting with unilateral left foot drop

Li Adrian P Z , Best Jonathan , Kariyawasam Dulmini , Brackenridge Anna , Thomas Stephen , Maltese Giuseppe

Case history: A 26-year-old lady presented with a two-week history of weakness associated with pins and needles affecting the lateral calf and dorsomedial aspect of her left foot. The patient denied any trauma or symptoms including weight loss. She had no drug allergies and was taking no regular medications. She had a vegan diet supplemented with multivitamins. Her past medical and family history was unremarkable. On examination, she had a narrow-based high-steppage-gait. Lowe...

ea0021p286 | Pituitary | SFEBES2009

Oral and transdermal oestrogen treatments have differing effects on GH sensitivity in hypopituitary women receiving GH replacement

Tanna Amit , Madula Rajiv , Sandhu Harinderjeet , Powrie Jake , Thomas Stephen , Brackenridge Anna , Breen Louise , Carroll Paul

Background: The route of oestrogen replacement has an influence on GH sensitivity in hypopituitary women, although the practical relevance of this effect remains unclear.Objectives: To compare the effects of oral and transdermal oestrogen replacement on GH requirement in adult females with hypopituitarism receiving GH replacement.Methods: This cross-sectional, observational study included 69 GH-deficient women each receiving a stab...

ea0019p323 | Steroids | SFEBES2009

Long-term consequences of auto-immune primary adrenal failure

Breen L , Thomas S , Doherty E , Powrie J , Brackenridge A , Carroll P

Background: Auto-immune Addison’s disease (AAD) is the most prevalent cause of primary adrenal insufficiency in the UK. Co-morbidities are commonly associated with AAD and can manifest years after the initial diagnosis. There is no clear consensus on the optimal surveillance and management of this condition.Objectives: To establish the prevalence of co-morbidities, assess bone health and review clinical surveillance practice of patients attending an...

ea0013p97 | Clinical practice/governance and case reports | SFEBES2007

Endocrine hypofunction as a consequence of metastatic cancer

Srinivasan R , Flood J , Thomas SM , Brackenridge AL , Carroll PV , Powrie JK

Introduction: Endocrine deficiency as a result of glandular infiltration by metastatic cancer is considered rare. Metastases to the adrenal cortex are relatively common and we present the clinical presentation and radiological appearances of cases involving pituitary and adrenal metastases.Case histories: Case 1: An 84 year old male with bronchogenic carcinoma presented with lethargy, polyuria and dehydration. The serum Na+ was 156 mmol...

ea0013p210 | AMEND Young Investigator's Award | SFEBES2007

Routine preoperative venous sampling is not necessary in aldosterone producing adenoma (Conn’s syndrome)

Srikugan Lanitha , Thomas Stephen M , Powrie Jake K , Howard Jonathan , Brackenridge Anna , Carroll Paul V

Controversy exists as to the role of adrenal venous sampling in the assessment of primary aldosteronism (PA). There is no consensus as to how best to define successful outcome post resection of aldosterone producing adenoma (APA). We performed a retrospective analysis of the outcome of patients following unilateral adrenalectomy without pre-operative venous sampling. The study included 14 patients (9 males; mean age 47 yrs (r: 38–59 yrs) with PA and CT identified u...