Searchable abstracts of presentations at key conferences in endocrinology

ea0034p16 | Bone | SFEBES2014

Role of cortisol in the pathogenesis of postmenopausal osteoporosis: relationship to bone structure

Debono Miguel , Bratherton Selina , Paggiosi Margaret , Gossiel Fatima , Keevil Brian , Ross Richard , Eastell Richard

Background: Excess glucocorticoids are well recognised as a cause of osteoporosis; they inhibit osteoblast function and increase osteoblast and osteocyte apoptosis resulting in thinning of the trabeculae. The circadian rhythm of bone turnover, which is linked to cortisol rhythm, is abnormal in osteoporosis. Furthermore, some studies show abnormal cortisol metabolism in osteoporosis. The aim of our study was to evaluate the day┬ľnight rhythm of cortisol and to relate cortis...