ea0063oc9.2 | Thyroid 2 | ECE2019
Rodriguez Alfonso Ruben Ruiz
, Braun Doreen
, Schweizer Ulrich
The main product of the thyroid gland, T4, is a prohormone. 5-deiodination is needed to convert T4 into the active, nuclear receptor-binding hormone, T3. Pharmacological modulation of activating 5-and inactivating 5-deiodination of iodothyronines would be desirable in a number of medical conditions, including hypothyroidism, hyperthyroidism and various cancers. A structural and mechanistic understanding of deiodinase (DIO) catalysis...