Searchable abstracts of presentations at key conferences in endocrinology

ea0014p32 | (1) | ECE2007

Effects of rosiglitazone (RGZ) and pioglitazone (PGZ) on serum androgens and urinary steroid profile in patients with type 2 diabetes: A prospective, randomised cross-over study

Chappuis Bernard , Braun Monika , Stettler Christoph , Diem Peter , Christ Emanuel

Background: Glitazones (GZ) influence androgen biosynthesis in PCO syndrome. At present it is unknown whether a) steroid hormone metabolism is influenced by GZ in patients with type 2 diabetes b) there is a differential effect of RGZ and PGZ on steroid hormone metabolism c) this effect is sex-specific and d) this effect is mediated by changes in insulin sensitivity. Therefore, urinary steroid profiles and serum total testosterone and DHEA levels were analysed before and after ...