Searchable abstracts of presentations at key conferences in endocrinology

ea0059s9.1 | Introduction and prevention of gonadal function | SFEBES2018

How do I differentiate hypog hypog from constitutional delay?

Bridges Nicola

Constitutional delay is a common presentation to paediatric endocrine clinics. Most are boys who have been at the bottom of the normal range for height during childhood and then started to feel left behind as their peers develop in puberty. There is no agreed cut off age but most boys referred are 13–15 years old. Most boys with delay of puberty are healthy, although there is an association with chronic medical conditions (eg inflammatory bowel disease, juvenile rheumatoi...

ea0027s5 | CME Session | BSPED2011

Other forms of diabetes

Bridges Nicola

Diabetes which is not type 1 or type 2 makes up a very small proportion of all diabetes cases in children and adolescents. The value of recognising these is that treatment and outcome can be very different from that seen in type 1 or 2.Other forms of diabetes can be divided into several groups: 1. Genetic diabetes including MODY and neonatal diabetes. MODY can be confused with type 1 diabetes in children. Making the diagnosis can b...

ea0039ep35 | Diabetes | BSPED2015

Retrospective baseline services audit regarding the nature of emergency department attendances by registered diabetic children

Kim Ji Soo , Bridges Nicola , Alexander Saji

Objectives: Many paediatric diabetes units in the UK have introduced 24 h telephone support to encourage self-management to reduce Emergency Department (ED) attendances and admissions. The UK national audit collects information on acute paediatric diabetic admissions; but there is no data available on ED attendances in this group. We undertook a retrospective audit of ED attendances as part of a baseline service evaluation of our newly introduced 24 h support service.<p cl...

ea0051p066 | Diabetes | BSPED2017

Clinical implications of changes to fluid therapy in 2015 BSPED DKA guideline – a comparative audit, pre and post guideline implementation.

Siow Selena , Bridges Nicola , Aminu KIngi , Alatzoglou Kyriaki , Alexander Saji

Introduction: In August 2015, the British Society for Paediatric Endocrinology and Diabetes (BSPED) released new guidelines for the management of DKA. These new guidelines recommended a much more conservative approach with fluid management in order to reduce the risk of cerebral oedema.Aim: Based on local anecdotal evidence, we hypothesized that with the new guidelines, we have had to increase maintenance fluid infusion rates more often and that the chil...

ea0058p035 | Miscellaneous Endocrinology | BSPED2018

Use of recombinant human growth hormone in a neonate with Prader Willi Syndrome to improve respiratory status

Shaunak Meera , Dimitrova Svilena , Bridges Nicola , Bhandari Jasjit

Background: Prader Willi Syndrome (PWS) is a disorder of genetic imprinting caused by uniparental disomy of chromosome 15. It can present in the neonatal period with dysmorphic features, hypotonia and feeding difficulties. In the UK, recombinant human Growth Hormone (rhGH) is licensed for use in PWS, improving body composition and motor development, as well as final adult height. Some studies have also demonstrated an improvement in respiratory function in children with PWS. T...

ea0033p60 | (1) | BSPED2013

Dumping syndrome an often unrecognised problem following post nissen fundoplication, gastrostomy in infants

Kalaivanan Prabhakaran , Spowart Karen , Bridges Nicola , Alexander Saji

Background: Dumping syndrome in infants who have undergone gastrostomy or Nissens fundoplication is a recognised phenomenon. The pathogenesis is possibly due to a bolus feed causing an incretin effect and leading to hyperinsulinaemic hypoglycaemia. Continuous glucose monitoring (CGM) systems have not been used in the past to study this phenomenon. We report CGM findings which are almost identical on three such post surgical infants.Case series 1: a 36-we...

ea0039ep29 | Diabetes | BSPED2015

Factors influencing type 1 diabetes control in children – a detailed local analysis of an NPDA dataset

Fang Clarissa , Trewella Emily , Aminu Kingi , Spowart Karen , Bridges Nicola , Alexander Saji

Background: National paediatric diabetes audit (NPDA) provides comparative data for local paediatric diabetes units (PDUs) on key care processes and overall HbA1c. More detailed analysis on other variables affecting HbA1c is undertaken at a national level, but not at an individual PDU level.Objective: To determine the factors influencing glycaemic control (HbA1c levels) in young children and adolescents with Type 1 Diabetes Mellitus (T1DM).<p class="...

ea0039ep47 | Diabetes | BSPED2015

Characteristics of newly diagnosed children with type 1 diabetes – DKA vs Non- DKA presentation

El Munshid Sarrah , Alexander Saji , Spowart Karen , Logan Karen , Aminu Kingi , Bridges Nicola

Background: Diabetic ketoacidosis (DKA) is a common presentation of newly diagnosed type 1 diabetes (T1DM) in children but increases the disease burden at diagnosis. In UK, average frequency of DKA presentation is reported as 25% with an international variation of 16 to 67%. Data on frequency variations within the UK is limited.Aim: To compare the demographic and clinical characteristics of DKA vs non-DKA presentations in children <16 years at diagno...

ea0045oc6.7 | Oral Communications 6- Endocrine | BSPED2016

Early treatment with rhGH in patients with Prader-Willi syndrome results in improved height with no respiratory adverse effects

Alatzoglou Kyriaki , Gopalakrishnamoorthy Mahalakshmi , Trewella Emily , Mulla Aayesha , Tan Hui-Leng , Bridges Nicola

Background: Prader-Willi syndrome (PWS) is a complex genetic disorder caused by lack of expression of paternally inherited imprinted genes on Chr15q11-q13. rhGH has beneficial effects on growth, body composition and development. Starting age, dose titration and monitoring remain controversial.Objective: To study retrospectively children who presented in our multidisciplinary PWS clinic and assess response to rhGH treatment in terms of auxology, IGF1 conc...

ea0045p34 | Diabetes | BSPED2016

Continuous Subcutaneous Insulin Infusion results in better glycaemic control and reduced insulin requirements in CFRD: Report of 2 cases in children

Trewella E F , Spowart K , Nambisan A Kesavath Raman , Nolan SE , Carr S , Balfour-Lynn I M , Alexander Saji , Bridges Nicola

Introduction: Continuous Subcutaneous Insulin Infusion (CSII) has several advantages over Multiple Daily Injections (MDI) including better hourly delivery and avoidance of injections. However usage of CSII is significantly less in Cystic Fibrosis Related Diabetes (CFRD) compared to type 1 diabetes and published literature on use of CSII in children and adolescents with CFRD is minimal.We report two cases where CSII was used in CFRD resulting in a lower T...