Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp245 | Thyroid Cancer & Thyroid Case Reports | ECE2017

A statistical, in silico model predicts polygenic thyroid cancer risk

Casarini Livio , Marino Marco , Nuzzo Federico , Simoni Manuela , Brigante Giulia

Introduction: The detection of a unique genetic marker is not possible for multifactorial diseases, such as thyroid cancer (TC), where the pathological phenotype is given by the contribution of multiple genes, environmental factors and lifestyle. We found a mathematical model for inferring the risk of thyroid cancer, an example of multifactorial disease.Methods: Genetic data represented by 184 SNPs associated to thyroid tumors were used for Bayesian clus...

ea0037ep210 | Reproduction, endocrine disruptors and signalling | ECE2015

Serum gonadotropins secretion is not reduced with advancing age in HIV-infected females: results of a case–control study in menopausal women

Diazzi Chiara , Brigante Giulia , Guaraldi Giovanni , Simoni Manuela , Rochira Vincenzo

Introduction: HIV infection treated with highly active antiretroviral therapy (HAART) seems to be associated with hypogonadism in men. Less is known in HIV-infected women gonadal status. The aim of this study is to investigate gonadal function, in menopausal HIV-infected women compared sex- and age-matched healthy subjects (HS).Methods: We retrospectively compared 188 HIV-infected women with 192 HS selected reviewing record charts and laboratory database...

ea0081p327 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Retrospective observational study of Italian patients with diabetes mellitus in Covid-19 era: a big data approach

Greco Carla , Pirotti Tommaso , Brigante Giulia , Filippini Tommaso , Pacchioni Chiara , Trenti Tommaso , Simoni Manuela , Santi Daniele

Introduction: The prevalence of diabetes mellitus (DM) in patients with coronavirus disease (COVID)-19 varies widely, depending on population characteristics, country, age and disease severity. Moreover, pre-existing DM seems to double the risk of both critical COVID-19 and mortality.Aim: To evaluate incidence and mortality risk of COVID-19 in a large diabetic population in Northern Italy.Methods: A retrospective, observational, bi...

ea0067o1 | Oral Presentations | EYES2019

Prevalence of thyroid disfunctions in a large cohort of Human Immunodeficiency Virus (HIV)-Infected Patients

Tartaro Giulia , De Vincentis Sara , Brigante Giulia , Diazzi Chiara , Malagoli Andrea , Guaraldi Giovanni , Rochira Vincenzo

Objective: Highly Active Antiretroviral therapy (HAART) has been associated with several endocrine abnormalities. Data concerning thyroid dysfunction in HIV are still controversial. The aim of this study was to investigate the prevalence of thyroid dysfunctions and their association with HAART and HIV-infection in a large cohort of HIV-infected patients.Methods: A retrospective cross-sectional study was carried out involving HIV-infected patients whose t...

ea0049ep1383 | Thyroid (non-cancer) | ECE2017

Thyroid nodules ultrasound classification and the importance of the endocrinologist clinical feeling

Madeo Bruno , Brigante Giulia , Ansaloni Anna , Taliani Erica , Simoni Manuela , Rochira Vincenzo

Background and aim of the study: Several ultrasound (US) classifications for estimating thyroid nodules risk have been proposed. Since most of them are hardly applicable in clinical practice, we created a local tool, named Modena classification (MC), considering US characteristics and clinician subjective impression. The aim is to verify the diagnostic accuracy of MC and to compare it to US classifications of American Thyroid Association(ATA) (1) and British Thyroid Associatio...

ea0037oc6.2 | Thyroid | ECE2015

Biological activity of novel thyroid hormone analogues: role of Na+ taurocholate cotransporting polypeptide in liver selectivity

Brigante Giulia , Carlsson Bo , Kersseboom Simone , Peeters Robin P , Visser Theo J

Background: The interest in the potential effect of thyromimetics in lowering serum cholesterol is growing. Thyroid hormone actions on lipid metabolism are exerted in the liver and mediated by the T3 receptor TRβ1. The creation of molecules transported into hepatocytes by liver-specific transporters can increase the liver selectivity of thyromimetics. Sodium taurocholate co-transporting polypeptide (NTCP), a solute carrier protein primarily expressed on the basolateral me...

ea0035p924 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

GH Deficiency in HIV-infected patients compared to hypopituitary patients

Diazzi Chiara , Brigante Giulia , Ferrannini Giulia , Guaraldi Giovanni , Ansaloni Anna , Simoni Manuela , Rochira Vincenzo

Introduction: Growth Hormone deficiency (GHD) is frequent in patients with human immunodeficiency virus 1 (HIV-1), undergoing highly active antiretroviral therapy. GHD seems to depend on HIV-related lipodystrophy and to be less frequent in women.Aim of the study: To investigate the association of gender, body composition and GH/IGF1 axis, and to clarify whether GHD in HIV-infected patients is functional or a clinical entity.Methods...

ea0035p1053 | Thyroid (non-cancer) | ECE2014

Thyroid volume in adult β-thalassemic patients is smaller than in controls

Ansaloni Anna , Diazzi Chiara , Santi Daniele , Brigante Giulia , Ferrara Francesca , Pietrangelo Antonello , Rochira Vincenzo

Introduction: Thyroid function is commonly impaired in β-thalassemic patients with an estimated prevalence of hypothyroidism of 9–11%. According to literature, iron overload is the main cause of tissue damage involving both thyroid and pituitary gland, thus leading to primary or secondary hypothyroidism respectively. However, thyroid morphology has been rarely investigated in adults. The aim of this study is to evaluate thyroid volume (TV) and thyroid morphology in &...

ea0070aep781 | Reproductive and Developmental Endocrinology | ECE2020

Luteinizing hormone/choriogonadotropin receptor (LHCGR) mediates different kinetics of G proteins, β-arrestins and cAMP activation

Paradiso Elia , Benevelli Riccardo , Lazzaretti Clara , Sperduti Samantha , Brigante Giulia , Simoni Manuela , Casarini Livio

Pituitary luteinizing hormone (LH) and placental human choriogonadotropin (hCG) are two heterodimeric glycoprotein hormones regulating reproduction. They bind the same receptor (LHCGR) expressed in gonadal cells, activating hormone-specific G protein- and β-arrestins-dependent signaling cascades, before LHCGR internalization. LH induces preferential proliferative signals, while hCG activates mainly the steroidogenic pathway, reflecting their physiological roles. In this s...

ea0070aep921 | Thyroid | ECE2020

Early diagnosis of medullary thyroid cancer in case of low serum calcitonin: Role of calcitonin measurement in fine-needle aspiration washout fluid

Greco Carla , Madeo Bruno , Rochira Vincenzo , Cristina De Santis Maria , Brigante Giulia

Background: Screening serum calcitonin (sCT) measurement in patients with thyroid nodules is still debated. Moreover, sCt cutoffs for medullary thyroid carcinoma (MTC) are not univocally defined. Also, sensitivity of cytology by fine needle aspiration biopsy (FNAb) has been demonstrated to detect approximately half of MTCs. Ct measurement in fine-needle aspiration washout fluid (Ct-FNAb) has high sensitivity and specificity and is helpful in case of non-diagnostic cytology&#18...