Searchable abstracts of presentations at key conferences in endocrinology

ea0028p163 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Testosterone replacement therapy has beneficial effects on Cardiovascular risk factors and liver function in hypogonadal men

Brooke Jonathan , Walter Debbie , Muraleedharan Vakkat , Jones T Hugh

Introduction: Low testosterone levels are associated with cardiovascular morbidity and an increased risk of non-alcoholic steatohepatitis (NASH). NASH is closely associated with insulin resistance and atherosclerosis.AIM: We studied the effect of long-term testosterone replacement therapy (TRT) on liver function and cardiovascular risk factors in hypogonadal men.Method: Retrospective audit of 308 hypogonadal men receiving TRT as in...

ea0028p182 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Testosterone Inhibits Key Enzymes of Fatty Acid Synthase and Protects Against Hepatic Steatosis in the Tfm Mouse

Kelly Daniel , Brooke Jonathan , Muraleedharan Vakkat , Akhtar Samia , Channer Kevin , Jones Hugh

Objectives: A clinical feature of insulin resistance is the development of fatty liver (hepatic steatosis). Testosterone deficiency is common in men with type-2 diabetes and is associated with insulin resistance. The testicular feminised mouse (Tfm) exhibits a non-functional androgen receptor (AR) and low circulating testosterone. We have previously shown that a high-cholesterol diet promotes hepatic steatosis in Tfm mice, and testosterone replacement therapy (TRT) attenuates ...

ea0025p152 | Diabetes, metabolism and cardiovascular | SFEBES2011

Low testosterone and severity of erectile dysfunction (ED) are independently associated with poor health related quality of life (HRQoL) in men with type 2 diabetes

Brooke Jonathan , Walter Debbie , Muraleedharan Vakkat , Marsh Hazel , Kapoor Dheeraj , Jones T Hugh

Introduction: Both low testosterone levels and erectile dysfunction (ED) are highly prevalent in men with type 2 diabetes. Lower testosterone levels are known to be associated with worsening severity of ED as assessed using the International Index of Erectile Function score (IIEF). Testosterone deficiency and erectile dysfunction are both independently correlated with increased risk of cardiovascular disease.Aim: To investigate the effect of low testoste...