Searchable abstracts of presentations at key conferences in endocrinology

ea0016s5.4 | Protein modifications - proteomics | ECE2008

Progesterone receptor responses modified by SUMO in the endometrium

Brosens Jan

Cyclic AMP sensitizes human endometrial stromal cells (HESCs) to progesterone and promotes differentiation into decidual cells, a process indispensable for pregnancy. Our studies have shown that cAMP enhances progesterone responses, at least in part, by attenuating ligand-dependent sumoylation of the progesterone receptor (PR). In fact, decidualization is associated with global hyposumoylation and redistribution of SUMO-1 conjugates into distinct nuclear foci. This altered pat...

ea0031p306 | Pituitary | SFEBES2013

Regulation of LH/CG receptor signaling in human endometrium and perturbations in recurrent pregnancy loss

West Camilla , Hanyaloglu Aylin , Brosens Jan

G-protein coupled receptors (GPCRs) represent the largest family of signaling receptors in nature. Their diversity means they play key physiological roles and their dysfunction underlies many pathological conditions, thus they are the focus of many drug design programs due to their primary biological and clinical importance. Our objective is to understand the fundamental mechanisms regulating hormone signaling via GPCRs. Disruption of GPCRs regulation in humans underlies many ...

ea0034p332 | Reproduction | SFEBES2014

Regulation of the LH/CG receptor signalling in human endometrium

West Camilla , Hanyaloglu Aylin , Brosens Jan , Lavery Stuart , Panay Nick

It is well established that the interaction between an implanting embryo and the endometrium is essential for successful implantation and there is a variety of locally secreted factors within the uterine environment which underlies this maternal–fetal cross-talk. Human chorionic gonadotrophin (hCG) is a glycoprotein hormone secreted by the embryo and is essential during early stages of pregnancy to maintain progesterone production from the corpus luteum. Its receptor (LH/...