Searchable abstracts of presentations at key conferences in endocrinology

ea0077p187 | Metabolism, Obesity and Diabetes | SFEBES2021

Asprosin induces acute pro-inflammatory effects on THP-1 macrophages

Shabir Kiran , Brown James , Randeva Harpal , Kyrou Ioannis

Introduction: Asprosin is a novel adipokine that is released in response to fasting and can elicit orexigenic and glucogenic effects. Circulating asprosin levels are elevated in a number of cardio-metabolic diseases, including obesity and type 2 diabetes mellitus. In vitro studies have reported pro-inflammatory effects of asprosin in pancreatic β-cells and skeletal muscle cells, which appear to be mediated via a toll-like receptor 4 (TLR4) mediated pathway, and m...

ea0021p153 | Diabetes and metabolism | SFEBES2009

A role for aquaglyceroporins in adipogenesis

Brown James , Conner Matthew , Bill Roslyn , Ramanjaneya Manjunath , Bailey Clifford , Randeva Harpal , Conner Alex

Aims/objectives: Glycerol cycling plays an essential regulatory role in metabolism in both health and disease. Aquaporins (AQPs) are a recently described family of water transporting membrane proteins, which contain a subset of members that also have the ability to transport glycerol across the cell membrane. This study sought to investigate the adipose tissue expression profile of AQPs in humans, and to assess the role of AQPs in adipocyte differentiation.<p class="abstex...

ea0019oc7 | Young Endocrinologist prize session | SFEBES2009

In vivo and ex vivo regulation of Visfatin production by leptin in human and murine adipose tissue: role of the PI3K and MAPK pathways

Tan Bee , Chen Jing , Brown James , Adya Raghu , Ramanjaneya Manjunath , Bailey Cliff , Lehnert Hendrik , Randeva Harpal

Apart from its role in energy storage, adipose tissue produces several hormones and cytokines termed ‘adipokines’ that have wide-ranging effects on carbohydrate and lipid metabolism; and thereby, play an important role in the pathogenesis of the metabolic syndrome. Visfatin is a novel adipokine, levels of which increase in obesity and is adipogenic; properties common to that of leptin. Thus, leptin may modulate visfatin production in adipose tissue. We investigated t...

ea0019p131 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Identification of nesfatin-1/NUCB2 as a novel depot-specific adipokine in human and murine adipose tissue: aletered levels in obesity and food deprivation

Ramanjaneya Manjunath , Chen Jing , Brown James , Patel Suketu , Tan Bee , Randeva Harpal

NESFATIN-1 is a recently identified hypothalamic satiety molecule derived from its precursor protein, NEFA/nucleobindin2 (NUCB2). Although the hypothalamus is considered the cornerstone for maintenance of energy homeostasis, adipose tissue plays an important role in the integration of metabolic activity and energy balance; communicating with peripheral organs and the brain via secreted proteins, termed adipokines. Many hypothalamic satiety regulatory peptides have been describ...

ea0086p60 | Metabolism, Obesity and Diabetes | SFEBES2022

Asprosin exerts pro-inflammatory effects via the TLR4 pathway in THP-1 macrophages

Gharanei Seley , Shabir Kiran , Patel Vanlata , Brown James , Kyrou Ioannis , Randeva Harpal

Background: Adipose tissue exhibits an altered adipokine secretion profile in obesity which is pro-inflammatory and relates to higher risk of cardio-metabolic diseases. Asprosin is a novel pleiotropic adipokine with orexigenic and glucogenic effects which is secreted in response to fasting. Elevated circulating asprosin levels have been shown in obesity and type 2 diabetes, as well as in other cardio-metabolic diseases. Furthermore, in vitro studies have reported pro-...

ea0019p315 | Steroids | SFEBES2009

Orexin-stimulated MAP Kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: differential regulation by orexin A and orexin B

Chen Jing , Ramanjaneya Manjunath , Conner Alex , Kumar Prashanth , Brown James , Johren Olaf , Lehnert Hendrik , Stanfield Peter , Randeva Harpal

Orexin-A and orexin-B orchestrate their diverse central and peripheral effects via two G-protein coupled receptors, OX1R and OX2R, which activate multiple G-proteins. They are involved in a host of physiological processes including, steroidogenesis, appetite control and energy regulation. Whilst some signalling mechanisms have been proposed for individual recombinant orexin receptors in generic mammalian cell types, it is clear that the peripheral effects of orexin are spatial...