Searchable abstracts of presentations at key conferences in endocrinology

ea0019p125 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and insulin resistance on a high fat diet

Jamieson P , Cleasby M , Morton N , Kelly P , Wingate J , Brownstein D , Seckl J , Vale W

Urocortins are the endogenous ligands for the corticotropin-releasing factor receptor type-2 which is highly expressed in skeletal muscle where it regulates glucose metabolism and muscle mass. Transgenic mice overexpressing Urocortin-3 (UCN3+) show accelerated peripheral glucose disposal and increased skeletal muscle mass with myocyte hypertrophy associated with decreased energy efficiency and improved glucose tolerance. We aimed to determine whether this phenotype would confe...

ea0011oc9 | Steroids and reproductive endocrinology | ECE2006

11β-HSD1: anti-inflammatory mechanism in acute and chronic inflammation?

Coutinho AE , Gray M , Sawatzky DA , Brownstein D , Mullins J , Seckl JR , Savill JS , Chapman KE

Although the anti-inflammatory effects of exogenous glucocorticoids (GC) upon inflammation are well recognized, the contribution of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), an amplifier of GC action in vivo, in modulating endogenous GC action during inflammation is unknown. Mouse models of arthritis and lung inflammation were used to explore the role of 11β-HSD1 in acute and chronic inflammation. Arthritis was induced in 11β-HSD1−/&#...