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ea0021p25 | Bone | SFEBES2009

Extra-pituitary expression of the prolactin gene in the bone and cartilage of an hPRL-Luc transgenic rat model

Semprini Sabrina , McNeilly Judith R , Ramage Lindsay , Brownstein David G , Salter Donald M , McNeilly Alan , White Michael R H , Davis Julian R E , Mullins John J

Prolactin (PRL) is a peptide hormone produced by the anterior pituitary gland and it is commonly known for its lactogenic and mammotrophic effects. In humans and primates, prolactin is also expressed in extra-pituitary sites where it is associated with numerous biological functions, but its spectrum of expression varies in different species.Hyperprolactinemia-induced osteoporosis is believed to be mediated by hypogonadism, but the expression of the prola...

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ea0019oc9 | Neuroendocrine and Steroids | SFEBES2009

11β-hydroxysteroid dehydrogenase type 1 activity limits fibrosis following bleomycin lung injury by augmenting active glucocorticoids

Yang Fu , Duffin Rodger , Brownstein David G , Coutinho Agnes , Rossi Adriano G , Savill John S , Seckl Jonathan R , Chapman Karen E

Glucocorticoids are potent anti-inflammatory agents. Endogenous glucocorticoid action is modulated by 11β-hydroxysteroid dehydrogenase (11β-HSD) which interconverts active (cortisol, corticosterone) and intrinsically inert glucocorticoids (cortisone, 11-dehydrocorticosterone). 11β-HSD type 1 regenerates active glucocorticoids. 11β-HSD 1 highly expressed in the lung but its role is little explored.Immunohistochemical staining of mouse ...

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Endocrine Abstracts

Extra-pituitary expression of the prolactin gene in the bone and cartilage of an hPRL-Luc transgenic rat model

11β-hydroxysteroid dehydrogenase type 1 activity limits fibrosis following bleomycin lung injury by augmenting active glucocorticoids

BiosciAbstracts