Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp189 | Pituitary & endocrine Tumours | ECE2017

Evaluation of pituitary toxicity after radiotherapy for cerebral chondrosarcomas in adult patients

Laroche Suzanne , Feuvret Loic , Beauchet Alain , Dendale Remi , Chanson Philippe , Bruckert Eric , Jublanc Christel

Pituitary dysfunction can be a consequence of cranial radiotherapy. It usually occurs years after the treatment. However little is known on risk factors for pituitary dysfunction. The object of this study was to evaluate radiation induced pituitary toxicity of proton beam therapy in a cohort of adult chondrosarcoma patients.The files of 113 patients were reviewed. Mean age at the beginning of radiotherapy was 43 years old (18–76). Mean dose delivere...

ea0056gp69 | Cardiovascular | ECE2018

Can monogenic severe hypertriglyceridemia be differentiated from polygenic forms through clinical features: data from APPROACH and COMPASS studies in FCS and non-FCS hypertriglyceridemic patients?

O'Dea Louis , MacDougall James , Digenio Andres , Hubbard Brant , Arca Marcello , Moriarty Patrick , Kastelein John , Bruckert Eric , Witztum Joseph

Introduction: Differentiation between familial chylomicronemia syndrome (FCS), a rare hypertriglyceridemia, and severe hypertriglyceridemia (sHTG; non-FCS) is challenging due to overlap in triglyceride (TG) levels and symptomology but important in disease management. Clinical characteristics that allow for reliable differentiation may exist in the presenting clinical features and primary diagnostic testing. The objective of this analysis was to assess whether readily obtainabl...

ea0063p992 | Diabetes, Obesity and Metabolism 3 | ECE2019

IN-FOCUS France: an epidemiological survey on severe hypertriglyceridaemiae assessing the comparative burden of illness of familial chylomicronaemia syndrome (FCS) and multifactorial chylomicronaemia syndrome (MCS)

Moulin Philippe , Bouquillon Benoit , Valero Rene , Krempf Michel , Rigalleau Vincent , Ziegler Olivier , Verges Bruno , Lecerf Jean-Michel , Verdier Edouard , Charriere Sybil , Bruckert Eric

Background: Familial chylomicronaemia syndrome (FCS) is a rare, inherited disorder characterised by impaired clearance of triglyceride (TG)-rich lipoproteins from plasma, leading to severe hypertriglyceridaemia (HTG), which have major effects on both physical and mental health, and a markedly increased risk of acute pancreatitis. A large overlap in the phenotype between FCS and multifactorial chylomicronaemia syndrome (MCS) contributes to the inconsistency in how patients are ...