Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.27.04 | Thyroid – hyperthyroidism and treatment | ECE2015

TIM16 inhibition enhances sensitivity to paclitaxel and decreases calcitonin secretion by reducing mitochondrial membrane potential in a human medullary thyroid carcinoma cell line

Gagliano Teresa , Riva Eleonora , Tagliati Federico , Matteotti Daniele , Brugnoli Valentina , Sambugaro Silvia , Bondanelli Marta , Gentilin Erica , Falletta Simona , Benfini Katiuscia , Di Pasquale Carmelina , Guerrini Remo , Salvadori Severo , degli Uberti Ettore , Zatelli Maria Chiara

TIM16, a protein of the translocase complex TIM23 of the mitochondrial inner membrane, is encoded by the Magmas a gene. Magmas silencing has been associated with a greater sensitivity to apoptotic stimuli in pituitary adenoma cell lines. We recently demonstrated that in a human medullary thyroid carcinoma cell line (TT) compound 5, a TIM16 inhibitor, was not cytotoxic but enhanced the proapoptotic effects of staurosporine. The aim of our study is to verify whether mithocondria...