Searchable abstracts of presentations at key conferences in endocrinology

ea0103p100 | Diabetes 6 | BSPED2024

Werner syndrome – a rare presentation with acanthosis nigricans

Manwani Bharkha , Prasad Rathi , Brungs Rosemary

Introduction: As the prevalence of obesity increases, incidence of childhood onset type 2 diabetes mellitus (T2DM) has significantly risen, most children having a family member with T2DM. Acanthosis nigricans, marker of insulin resistance, is often noted on presentation. We describe a case of early-onset severe acanthosis nigricans and T2DM in a lean Asian Bangladeshi girl with a rare progeria partial lipodystrophy disorder, highlighting the benefit of genetic testing in unusu...

ea0103oc5.2 | Endocrine Oral Communications 1 | BSPED2024

Minipuberty: a golden phase for optimal treatment. recombinant gonadotropin therapy during minipuberty in males with hypogonadotropic hypogonadism: a case series

Castro Sebastian , Brungs Rosemary , Gevers Evelien , Howard Sasha R.

Introduction: The hypothalamic-pituitary-testicular (HPT) axis is highly active in healthy male newborns until 3-6 months of age. During this phase, namely ‘minipuberty,’ Sertoli cells are stimulated by follicle-stimulating hormone (FSH), increasing testis volume and serum levels of AMH and inhibin B. In addition, luteinizing hormone (LH) promotes testosterone synthesis in Leydig cells, contributing to normal penis size and testicular position in the scrotum. In cong...

ea0103p74 | Adrenal 2 | BSPED2024

Fluconazole induced 11β-hydroxylase inhibition

Brungs Rosemary , Taylor David , Agrawal Pankaj , Kapoor Ritika

Background: Patients receiving triazole antifungals can present with hypertension and hypokalaemia. These drugs are reported to cause variable inhibition of the steroidogenic enzymes 11β hydroxylase and 11β hydroxysteroid dehydrogenase type 2 (11βHSD2). The ensuing clinical picture is similar to congenital adrenal hyperplasia (CAH) due to 11β-hydroxylase deficiency or apparent mineralocorticoid excess (11βHSD2 deficiency), with posaconazole and itracon...