Searchable abstracts of presentations at key conferences in endocrinology

ea0038p232 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Functional significance of renal gene expression changes in a mouse model of ACTH-dependent Cushing’s syndrome

Monaghan Marie-Louise , Sime Nichole , Conway Bryan , Bailey Matthew , Kenyon Christopher

Renal functions in a mouse model of CushingÂ’s Syndrome have been characterised by analysing RNA expression complemented by immunohistochemistry studies. A microarray of kidneys from mice infused with ACTH for two weeks identified gene transcripts that were up-regulated (70) and down-regulated (49) more than two-fold. Four separate clusters of closely correlated genes (r> 0.97; P< 0.001) were investigated in more detail. One down-regulated cluster included histocom...