Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep256 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Real-world experience of Evolocumab for treatment of hyperlipidemia in an outpatient population

Iqbal Sajid , Tikriti Alia Al , Buckley Adam

BackgroundUse of Evolocumab as a monotherapy or in combination with other lipid lowering drugs reduces LDL-C by up to 60% in patients with or without familial hypercholesterolemia (FH), diabetes mellitus (DM), or coronary artery disease (CAD). Data regarding the efficacy of PCSK9 inhibitors in MENA populations is lacking.MethodRetrospective case review of all patients initiated on Evolocumab treatment at Impe...

ea0086p168 | Adrenal and Cardiovascular | SFEBES2022

Inclisiran for the treatment of hypercholesterolemia in clinical settings

Iqbal Sajid , Sabbour Hani , Ashraf Tanveer , Buckley Adam

Background: Inclisiran is the first clinically available small interfering RNA (siRNA)-based treatment, has been shown to reduce pro-atherogenic lipoproteins in patients with or without familial hypercholesterolemia (FH), diabetes mellitus (DM), or atherosclerotic cardiovascular disease (ASCVD), but has not been evaluated in Middle Eastern populations.Methods: Retrospective review of patients initiating inclisiran treatment for any indication at our cent...

ea0090p72 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Clinical profiling of Acanthosis nigricans in Emirati patients and its association with sex-specific differences in insulin secretion and insulin resistance: a case-control study

Al-Olabi Lara , Alkaf Budour , Buckley Adam J.

Background: Acanthosis nigricans (AN) is a cutaneous condition characterised by pigmented hyperkeratosis of the skin flexures and neck and occurs most commonly in association with hyperinsulinaemia and insulin resistance (IR). A high prevalence of hyperinsulinaemia and abnormal glucose intolerance has been reported in the Emirati population. Current knowledge of AN suggests that it is a strong visible cutaneous marker associated with IR and can precede the onset of hyperglycae...

ea0059p089 | Diabetes & cardiovascular | SFEBES2018

Comparison of the impact of camel milk and cow milk on blood glucose, insulin and GLP1 in healthy individuals

Moriarty Maura , Buckley Adam , Lessan Nader , Barakat Maha T

Background: Interest is rising in the use of traditional food as potential treatments for diabetes. In some arid regions camel milk is believed to have special health promoting properties. Some studies have linked consumption of camel milk to diabetes prevention in addition to describing hypoglycaemic effects in those with diabetes. The potential mechanism is incompletely understood.Aims: To investigate the impact on glucose metabolism after a mixed meal...

ea0059cc7 | Featured Clinical Cases | SFEBES2018

An Atypical Presentation of Multiple Endocrine Neoplasia Type 1

Haboosh Sara , Buckley Adam , Alkaabi Fatima , Todd Jeannie F

A sixty-four year old man presented for investigation of mild hypercalcaemia (2.68 mmol/L) incidentally discovered during preoperative workup for elective removal of a testicular cyst. He had no family history of renal stones. His younger brother had undergone a parathyroidectomy at the age of 60. His father died in a road traffic accident aged 54. His mother was 84 and had no history of endocrine disease. Urine calcium:creatinine excretion ratio was 0.0207, excluding familial...

ea0077p70 | Metabolism, Obesity and Diabetes | SFEBES2021

Real-world metabolic outcomes of semaglutide use in patients with type 2 diabetes: a retrospective study from a single centre in the United Arab Emirates

Allum Matthew , Buckley Adam , Lessan Nader , Mohammed Nagi , Suliman Mohamed , Suliman Sara , Elsheikh Mohgah

Background: The Glucagon-like peptide-1 receptor agonist (GLP1RA) semaglutide has shown improvements in glycaemia and other metabolic parameters for patients with type 2 diabetes (T2D) in clinical trials. Published real-world data are sparse and there are none from the Middle East where semaglutide became available in 2020.Method and Results: We retrospectively gathered data for 289 patients (median age 50 years (IQR 42-57), 36% female, 87% Emirati and 8...

ea0081p552 | Calcium and Bone | ECE2022

Parathyroid function index does not differentiate between Normocalcaemic primary hyperparathyroidism and Vitamin D deficiency associated secondary hyperparathyroidism

Siddiqui Mohsin S , Koramannil Radha Saradalekshmi , Iqbal Sajid , Buckley Adam , Lessan Nader

Background: Normocalcaemic primary hyperparathyroidism (NPHPT) can be considered as an early biochemical manifestation of hypercalcaemic primary hyperparathyroidism (PHPT). Vitamin D repletion and exclusion of other conditions is recommended before diagnosing NPHPT. It is often challenging to distinguish Vitamin D deficiency associated secondary hyperparathyroidism (SHPT) from NPHPT and the two conditions may coexist. A parathyroid function (PF) index [(Parathyroid hormone (PT...

ea0065p178 | Metabolism and Obesity | SFEBES2019

Glycaemic response to a mixed meal challenge: does camel milk preload confer an advantage?

Moriarty Maura , Buckley Adam , Ashraf Tanveer , Barakat Maha T , Lessan Nader

Camel milk provides a modest portion of the overall global milk share but is an important source of protein in arid regions. Perceived health benefits include anti-diabetic properties attributed to its unique composition. We hypothesise that exogenous insulin present in camel milk mediates a hypoglycaemic effect. In a randomised, double blind crossover study, eleven normoglycaemic individuals were allocated to receive a 300 kcal pre-load of camel milk or cow milk ten minutes p...

ea0065p216 | Metabolism and Obesity | SFEBES2019

Risk of sleep apnoea among Emirati patients with type 2 diabetes

Hassan Sama , Buckley Adam , Al Tameemi T , Fojas Esphie Grace , Barakat Maha T , Lessan Nader

Background: Type 2 diabetes (T2D) and obesity have been linked with sleeping disorders in general and obstructive sleep apnoea (OSA) in particular; both are highly prevalent amongst Emirati patients. However, little information is available in this population regarding the prevalence and symptomatology of OSA, its relationships with T2D and obesity, and its impact on health outcomes.Objectives: This study aims to investigate the risk of OSA based on the ...

ea0038oc4.2 | Diabetes and cardiometabolic complications | SFEBES2015

Thermal imaging as a novel non-invasive method to measure human brown adipose tissue activity in humans

Salem Victoria , Engbeaya Chioma Izzi , Jayasinghe Sriyani Maduka , Thomas David , Coello Christopher , Comninos Alexander , Buckley Adam , Rabiner Eugenii , Gunn Roger , Win Zarni , Tan Tricia , Bloom Stephen , Dhillo Waljit

Background: Obesity is a major medical health problem. Human brown adipose tissue (BAT) is potently activated by cold exposure and is a potential novel anti-obesity target. The current gold standard for measuring BAT activity in humans is 18F-FDG PET/CT. However it has two major limitations – exposure to ionizing radiation and high cost. Since BAT is a thermogenic organ located in the supraclavicular and neck regions, we hypothesised that an increase in tempera...