ea0037ep863 | Thyroid cancer | ECE2015
Barbieri Raquel Bueno
, Cunha Lucas Leite
, Bufalo Natassia Elena
, Villagelin Danilo
, Assumpcao Ligia Vera
, Maciel Rui Monteiro
, Cerutti Janete Maria
, Ward Laura Sterian
Despite the importance of the Ret receptor, it is clear that other signal transduction pathways, tyrosine kinase receptors, and tumours suppressor genes are involved in MTC tumorigenesis and progression. Differences in the clinical behaviour of patients harbouring the same Ret mutations may be related to these other genes. Alterations of genes involved in the G1 phase of the cell cycle, including the cyclins, CDKs and CDK inhibitors, are common events in neoplastic development...