ea0011p745 | Steroids | ECE2006
, Bujalska IJ
, Stewart PM
, Tomlinson JW
The pathological effects of glucocorticoids (GC) are exemplified by patients with Cushings syndrome who develop central obesity, insulin resistance and in some cases, type 2 diabetes mellitus. It is generally accepted that GC cause insulin resistance, however, both insulin and GC increase adipocyte differentiation. The question therefore arises as to how GC stimulate adipocyte differentiation whilst apparently making adipocytes insulin resistant. We have hypothesized tha...