Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep1132 | Endocrine tumours | ECE2015

High-dose treatment with somatostatin analogues in neuroendocrine tumours

Modica Roberta , Ramundo Valeria , Marciello Francesca , Marotta Vincenzo , Pizza Genoveffa , Carratu Anna Chiara , Roseto Chiara de Luca di , Buonomano Pasqualina , Giordano Carla , Trimarchi Francesco , Colao Annamaria , Faggiano Antongiulio

Somatostatin analogs (SSA) effectively control symptoms in neuroendocrine tumours (NET), besides showing antiproliferative activity. In progressive or metastatic NET, increasing SSA dose or shortening the dosing interval are common clinical practice, though empirical. Aim of this study is to evaluate efficacy and safety of high-dose SSA treatment in patients with progressive disease under standard SSA dose. Twenty-one patients (median age 56.8 years) with NET of different orig...

ea0035p534 | Endocrine tumours and neoplasia | ECE2014

Role of metformin on recurrence-free survival in neuroendocrine tumors

Marciello Francesca , Modica Roberta , Marotta Vincenzo , Ramundo Valeria , Prete Michela Del , Buonomano Pasqualina , Carratu Anna Chiara , de Luca di Roseto Chiara , Picillo Ester , Colao Annamaria , Faggiano Antongiulio

Introduction: Recent data suggest that metformin has antineoplastic properties in different type of cancer. Effects of metformin have never been investigated in neuroendocrine tumors (NET).We aim to determine the role of metformine on recurrence-free survival (RFS) in NET patients.Materials and methods: A retrospective analysis was conducted comparing NET patients with recent diagnosis (<3 year) of diabetes mellitus (with HbA1c...

ea0035p128 | Calcium and Vitamin D metabolism | ECE2014

Cinacalcet hydrochloride more efficiently controls serum calcium levels in mild-asymptomatic primary hyperparathyroidism without surgery criteria, as compared with surgical cases

Marotta Vincenzo , di Somma Carolina , Rubino Manila , del Prete Michela , Marciello Francesca , Ramundo Valeria , Sciammarella Concetta , Buonomano Pasqualina , Carratu Annachiara , de Luca di Roseto Chiara , Colao Annamaria , Faggiano Antongiulio

Context: Primary hyperparathyroidism (PHPT) is a common endocrine disease, characterized by the chronic elevation of serum calcium (Ca) levels induced by a long-standing increase of PTH concentrations. PHPT includes mild-asymptomatic and symptomatic forms. Cinacalcet is effective in lowering serum Ca levels in PHPT, but is indicated solely in mild-asymptomatic PHPT meeting surgery criteria. Management of non-surgical mild-asymptomatic PHPT is still a debated issue.<p class...