Searchable abstracts of presentations at key conferences in endocrinology

ea0056p864 | Pituitary - Clinical | ECE2018

An immunohistochemical study on pituitary adenomas

Burcea Iulia Florentina , Capatina Cristina , Poiana Catalina

Introduction: Pituitary adenomas (PA) represent approximately 15% of all intracranial neoplasms, with a global incidence of 15,20 per million per year. The immunohistochemical analysis of PA is necessary for diagnosis and plays an important role in the modern classification system of pituitary tumors.Material and methods: Samples from 142 surgically resected PA were studied immunohistochemically using antisera for 6 anterior pituitary hormones. Reticulin...

ea0081ep729 | Pituitary and Neuroendocrinology | ECE2022

Case report: a challenging gastrinoma in a patient with renal cell carcinoma

Ioana Paduraru Alina , Burcea Iulia Florentina , Poiana Catalina

Introduction: Gastrinomas are rare neuroendocrine tumours (NETs) that arise from enterochromaffin-like cells and produce gastrin. Most are discovered in the duodenum and pancreas. The clear cell type of renal cell carcinoma (RCC) is known for the expression of gastrin-releasing peptide receptor (GRP-R) and some studies have shown GRP can stimulate tumor cell proliferation and neoangiogenesis. Therefore, we present a case with metachronous development of renal cell carcinoma an...

ea0073aep568 | Pituitary and Neuroendocrinology | ECE2021

Managing pituitary disease during COVID-19 pandemic: A case report

Dumitriu Roxana , Burcea Iulia Florentina , Dusceac Roxana , Poiana Catalina

IntroductionThe COVID-19 pandemic has significantly affected health systems all over the world, putting on a hold medical care and delaying surgical interventions. Patients with pituitary tumors, especially those who associate hormonal hypersecretion or defficiency and mass effects represent a management challenge even in a non-pandemic time.Case descriptionA 41 years old, non-smoker, overweight, male patient...

ea0073ep127 | Endocrine-Related Cancer | ECE2021

Advanced metastatic disease in a low-grade pulmonary neuroendocrine tumor: a case report with partial response to targeted therapy

Cristiana Calin , Dusceac Roxana , Burcea Iulia-Florentina , Catalina Poiana

BackgroundIt has been well recognized that grade heterogenity exists within well-differentiated neuroendocrine tumors (WD-NETs). Targeted therapy plays an important role in metastatic disease control.Case presentationWe present the case of a 58-year-old male patient who was diagnosed with a pulmonary tumor on computer tomography (CT) and underwent a posterobasal left lobectomy. On immunohistochemical staining...

ea0081ep619 | Endocrine-Related Cancer | ECE2022

The different faces of a long-lasting metastasized pancreatic neuroendocrine tumor with calcitonin paraneoplastic secretion and cardiac carcinoid

Ilinca Diculescu Rucsandra , Burcea Iulia Florentina , Dumitrascu Anda Simona , Boldeanu Cosmin , Iftimie Madalina- Elena , Poiana Catalina

Introduction: Besides medullary thyroid carcinoma (MTC), increased calcitonin serum concentrations may be due, rarely, to neuroendocrine tumour (NET) ectopic secretion, especially those of the foregut (pancreatic/lung). Patients with NETs and right-sided heart failure due to cardiac carcinoid have a worse prognosis than those presenting without. Case presentation: We present the case of a 72-year-old female with a history of an initially considered well-...

ea0081ep968 | Thyroid | ECE2022

Thyrotoxicosis and multisystemic inflammatory syndrome in a patient with recent history of COVID-19

Cristiana Calin , Ioana Iulia Greere Daniela , Burcea Iulia Florentina , Poiana Catalina

Introduction: There is evidence on the association of subacute thyroiditis (SAT) and SARS-CoV-2 infection, the first case report being described in a young woman back in July 2020 (1). Multisystemic inflammatory syndrome in adults (MIS-A) is a rare complication of SARS-CoV-2, usually 2 to 12 weeks after initial infection. The development of Graves disease after SAT is rare, with approximately 31 reported cases, of which only 5 occurring in men (2). We pre...

ea0070ep280 | Pituitary and Neuroendocrinology | ECE2020

Rare occurence of two metachronous bladder tumours, of which one is neuroendocrine

Iulia Greere Daniela Ioana , Burcea Iulia Florentina , Dusceac Roxana , Bottiglieri Luca , Poiana Catalina

Introduction: Neuroendocrine tumors (NETs) are rare tumors that originate in cells from the neural crest, widely distributed in the body. Genitourinary (GU) NETs occurring in the bladder represent less than 1% of these primary malignancies. We present the case of a patient with two metachronous bladder tumors, of which one is NET.Case report: Male patient, 52–year-old, ex–smoker, known with hypertension, dyslipidemia and benign prostatic hype...

ea0081p688 | Pituitary and Neuroendocrinology | ECE2022

Implications of the 2017 WHO classification in the characterization of GH-secreting pituitary tumors

Burcea Iulia Florentina , Nicoleta Nastase Valeria , Raluca Ceausu Amalia , Dumitraşcu Anda , Maria Cimpean Anca , Raica Marius , Poiana Catalina

Introduction: Somatotroph pituitary adenomas (PAs) represent 10-15% of all resected PAs, exhibiting immunohistochemical (IHC) positivity for GH (growth hormone) and PIT-1 transcription factor (TF). The histopathological (HP) and IHC variability of each PA influences the phenotype, radiological features, and therapy response.Materials and methods: The study included 33 patients with acromegaly, with men: women ratio of 17:16. The HP-IHC characteristics we...

ea0067gp26 | Poster Presentations | EYES2019

Multiple endocrine neoplasia type 1 presented with gastric neuroendocrine tumor: a case report

Lambrinoc Diana , Morea Alexandru , Burcea Iulia Florentina , Duşceac Roxana , Poiană Cătălina

Background: Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome, characterized by primary MEN1 tumors: parathyroid, pancreatic and pituitary. We describe the case of a patient with MEN1 syndrome, initially presented with a gastric neuroendocrine tumor (NET).Case presentation: A 33-year-old male patient, initially treated for perforated gastric ulcer, presented 7 years later with dyspepsia, diarrhea and weight loss. Abdominal CT scan revea...

ea0081ep174 | Calcium and Bone | ECE2022

McCune Albright syndrome – a clinician’s challenge and a multidisciplinary approach: case report

Iftimie Mădălina Elena , Burcea Iulia Florentina , Moise Mihnea-Nicolae , Deculescu Rareş-Ştefan , Budulucă Larisa , Poiana Catalina

Introduction: McCune-Albright syndrome is a rare, heterogenous disorder, consisting of at least two of the following three features: polyostotic fibrous dysplasia, café-au-lait skin pigmentation and autonomous endocrine hyperfunction. We present the case of a patient with an atypical presentation of McCune Albright syndrome (MAS) and severe fibrous dysplasia lesions.Case report: An 18-year-old girl diagnosed with MAS (at the age of four) was referre...