Endocrine Abstracts

The aim of this study was to investigate seasonal variation in haemoglobin A1c (HbA1c) using a retrospective population analysis linking HbA1c values to the time of year. The study cohort included 171 442 NHS patients from Scotland, UK. Patients were divided into three groups. The ‘stable group’ were defined as having a HbA1c that varied less than the tertile either side of the mean HbA1c. The ‘high summer’ was comprised of ...

Introduction: The two major long-acting somatostatin analogues (SSA) available on the European market for the treatment of neuroendocrine tumours and acromegaly are Somatuline Autogel (SA) and Sandostatin LAR (LAR). The aim of this study was to gain nurses’ insights on the use and ease of administration of SSA devices, including Somatuline Autogel new device (SA-ND), in Europe and the US.Methods/design: Seventy-seven qualified nurses with ≥3 S...

MEN 1 is an autosomal dominant syndrome associated with benign and malignant neuroendocrine neoplasia. It is characterised by primary hyperparathyroidism, pituitary neoplasia and foregut lineage neuroendocrine tumours. It has also been associated with premature cardiovascular death. Since diabetes is associated with an increased risk of cardiovascular mortality we investigated the prevalence of diabetes (DM) and impaired fasting glucose (IFG) in a large cohort of patients with...

Background: Primary hyperaldosteronism (PHA) typically manifests as resistant hypertension, hypokalaemia and metabolic alkalosis. We present a case of PHA who subsequently exposed type 4 renal tubular acidosis (RTA) after surgical intervention.Case history: A 62 year old man underwent investigation for chronic resistant hypertension, which had failed to respond to titration of three antihypertensive agents including Perindopril, Amlodipine and Doxazosin....

A 34-year-old primi gravida, 11 weeks into pregnancy, presented with hypertension (blood pressure 170/110 mmHg) proteinuria and hypokalaemia. She gave a 6-week history of tiredness, weight gain, and easy bruising. On examination, there was marked facial puffiness, non pitting oedema, thin skin with multiple bruises, marked proximal myopathy and no pigmented striae. Pregnancy associated Cushing’s was suspected.Investigations: Hypokalaemia (K+</s...

Background: Neurofibromatosis type 1 (NF1) related Phaeochromocytoma is a rare endocrine disorder and diagnosis is frequently delayed. NF1 is frequently associated with gastro-intestinal stromal tumour but also reported with adenocarcinoma (rare genetic MLH1 mutation). We presented a case where diagnosis of phaeochromocytoma was delayed 5 years after initial symptoms and only incidentally found on scanning at the time of his presentation with colonic...

Background: Neurofibromatosis type 1 (NF1) related Phaeochromocytoma is a rare endocrine disorder and diagnosis is frequently delayed. NF1 is frequently associated with gastro-intestinal stromal tumour but also reported with adenocarcinoma (rare genetic MLH1 mutation). We presented a case where diagnosis of phaeochromocytoma was delayed 5 years after initial symptoms and only incidentally found on scanning at the time of his presentation with colonic...

Pheochromocytoma is a rare disorder of chromafin cells and can be incidentally found in 20% of adrenal masses. It can be malignant in upto 10% of the cases. Metastatic disease poses a great challenge and no definitive cure is yet established to treat these tumors.We report a case of 54-year-old male patient with past medical history of anxiety who presented with acute left sided abdominal pain to the urology department at Norfolk and Norwich University H...

Background: Adrenal incidentalomas (AI) are asymptomatic adrenal lesions found on imaging not primarily performed to detect adrenal disease. We conducted a retrospective audit of management of AI following European Society of Endocrinology recommendation (2016).Methods: This was a retrospective review of incidentaloma referrals over 9 months (June 2017–March 2018). Cases were identified using criterion search of the referral console. Additional data...

Introduction: Pheochromocytomas (adrenal and extra- adrenal/Paragangliomas) are rare catecholamine producing tumors and required complex dedicated MDTintervention. We preliminarily reported our service in a tertiary referral centre over 10 years (2008–2018).Method: A retrospectively review of confirmed phaeochromocytoma were carried out by reviewing clinical correspondences and ICE investigation-result system (laboratory, radiology and histology.)</...