ea0009oc36 | Oral Communication 5: Thyroid | BES2005
Kim D
, Stratford A
, Boelaert K
, Pemberton H
, Gockce C
, Eggo M
, Tannahill L
, Watkinson J
, Franklyn J
, McCabe C
Cancer reflects the progressive accumulation of genetic alterations and subsequent genetic instability of cells. Differentiated thyroid cancers exhibit aneuploidy; cytogenetic studies have demonstrated the importance of genetic instability in thyroid cancer development. Pituitary tumour transforming gene (PTTG), also known as securin, is a mitotic checkpoint protein which inhibits sister chromatid separation during mitosis. PTTG is highly expressed in many cancers and over-exp...