ea0063p621 | Diabetes, Obesity and Metabolism 2 | ECE2019
, Allas Soraya
, Cade Didier
, Briffaux Jean-Paul
, Spencer Andrew
Prader-Willi syndrome (PWS) is a rare complex endocrine disease characterized by hyperphagia and abnormal food-related behaviors that contribute to severe morbidity and early mortality and to a significant burden on patients and caregivers. There are no approved treatments for hyperphagia in PWS. Patients with PWS have increased circulating levels of the orexigenic hormone acylated ghrelin (AG) with a relative deficit of unacylated ghrelin (UAG). These abnormalities in AG and ...