Endocrine Abstracts

IntroductionCorticosteroids play an essential role in the management of many rheumatic diseases. However, corticosteroids are associated with many adverse effects, including hyperglycaemia, dyslipidaemia, and osteoporosis. These adverse effects are dose related and patients on high dose, long term steroids (defined as > 5 mg oral prednisolone and treatment duration > 3 weeks) are at greatest risk. NICE guidelines on corticosteroids recommend moni...

Infected thyroid cysts are a rare complication of the thyroid gland, with haematogenous spread from a distal site of infection believed to be one mechanism of infection. We report the case of a patient who presented with an infected thyroid cyst due to Capnocytophaga canimorsus bacteraemia after sustaining a dog bite on her hand. A 37-year-old female presented to the Emergency Department with a five-day history of fevers, neck pain, and a rapidly enlarging neck swelling. The p...

Atezolizumab, a programmed death-ligand 1 (PD-L1) inhibitor, has been associated with development of several immune-related adverse events. Type 1 diabetes mellitus (T1DM) is considered a rare adverse event, described in 0.2-0.9% of patients treated with PD-L1 inhibitors. We present the case of a 67-year-old lady, who was diagnosed with extensive-disease small cell lung cancer. She received four cycles of carboplatin, etoposide and atezolizumab, and thereafter maintenance ther...

Renal glucosuria is a rare cause of hypoglycaemia. We describe an 18-year-old female who presented with a 2-year history of recurrent episodes of light-headedness and headaches. Glucometer readings during these symptoms demonstrated hypoglycaemia as low 2.1 mmol/l. She also had a 4-year history of recurrent urinary tract infections. Multiple dipstick urinalyses with GP demonstrated glucosuria, which was quantified with a 24-hour urinary glucose elevated at 4g/1.73m 2</sup...

Objective: We examined our cohort of adults with type 1 diabetes who are using hybrid closed-loop (HCL) insulin delivery systems, to describe what proportion are meeting international targets of HbA1c, time-in-range, and time spent below range. We assessed longitudinal changes in HbA1c associated with switching from an open-loop to a HCL insulin pump.Methods: We undertook a single-centre observational study of patients using Medtronic™ 780G insulin ...