Searchable abstracts of presentations at key conferences in endocrinology

ea0016p610 | Reproduction | ECE2008

Quantitative determination of aromatase and 5-α reductase mRNA and polymorphisms in the aromatase and 5-α reductase genes in idiopathic hirsutism

Dundar Munis , Okay Caglayan A , Baysal Nuran Ahu , Tanriverdi Fatih , Ozkul Yusuf , Unluhizarci Kursad , Kelestimur Fahrettin

Objective: Hirsutism, affects between 5% and 10% of women during reproductive age. Hirsutism associated with normal ovulatory function and normal circulating androgen concentrations is defined as idiopathic hirsutism and little information is available regarding the molecular pathogenesis.Aim: Significance of polymorphisms of the genes involved in androgen/oestrogen biosynthesis (SRD5A2,CYP19) and their expressions inmodulating the susceptibility ...

ea0014p10 | (1) | ECE2007

Normalization of serum testosterone level alters local GnRH-II and IL-2R mRNA expression in peripheral lymphocytes in patients with idiopathic hypogonadotrophic hypogonadism (IHH)

Tanriverdi Fatih , Akalin Hilal , Caglayan Okay , Demirkoparan Umit , Ozkul Yusuf , Dundar Munis , Bayram Fahri , Kelestimur Fahrettin

Although the existence of the interaction between sex steroids and immune system is well known, the mechanisms of this interaction are still unclear. Recently a second form of GnRH (GnRH-II) has been described in human, which is significantly expressed in immune tissues suggesting a potential function. In a recent in-vitro study it has been demonstrated that GnRH-II decreases local expression of IL-2R in peripheral lymphocytes (1). However in-vivo interactions of...