Searchable abstracts of presentations at key conferences in endocrinology

ea0035p371 | Diabetes (epidemiology, pathophysiology) | ECE2014

GCK-MODY caused by a new mutation in the GCK gene

Caldas Ana Rita , Pereira Teresa , Tavares Purificacao , Cardoso Maria Helena

Introduction: Glucokinase-MODY (Maturity onset diabetes of the young) results from heterozygous mutations in the GCK gene, impairing its enzymatic activity. GCK acts as a glucose sensor in the pancreatic beta cell and regulates insulin secretion. We describe two cases of MODY due to a GCK gene mutation not described until now.Clinical Case: A 63-year-old male is followed in our hospital for 30 years due to diabetes mellitus (DM). He was diagnose...

ea0037ep642 | Obesity and cardiovascular endocrinology | ECE2015

Patients' expectations and post-bariatric surgery satisfaction

Garrido Susana , Silva Isabel , Goncalves Luisa , Caldas Ana Rita , Cardoso M Helena

Introduction: Treatment satisfaction is simultaneously a cause and consequence of the success of bariatric surgery – not only it is a reflection of the efficacy of treatment, it also enhances weight loss. A questionnaire that evaluates this variable has recently been created and validated by the authors (Post-Bariatric Surgery Satisfaction Questionnaire).Objectives: To identify patients’ expectations regarding bariatric surgery; to identify the...

ea0037ep646 | Obesity and cardiovascular endocrinology | ECE2015

Influences on post-bariatric surgery satisfaction

Garrido Susana , Silva Isabel , Goncalves Luisa , Caldas Ana Rita , Cardoso M Helena

Introduction: Post-bariatric surgery satisfaction relies on psychosocial and clinical factors. A questionnaire that evaluates this variable has recently been created and validated by the authors (Post-Bariatric Surgery Satisfaction Questionnaire).Objective: To assess the relationship between treatment satisfaction and several demographic and clinical variables.Methods: Patients submitted to bariatric surgery who presented to our Ob...

ea0029p246 | Calcium & Vitamin D metabolism | ICEECE2012

High levels of parathormone after parathyroidectomy in primary hyperparathyroidism patients does not always mean disease recurrence…

Ferreira M. , Silva A. , Caldas A. , Dores J. , Freitas C. , Costa M. , Canha A. , Polonia J. , Vilaverde J.

Introduction: Primary hyperparathyroidism (PHPT) patients who undergo parathyroidectomy can develop isolated intact parathormone (iPTH) elevation with normal calcemia. Common causes are: renal insufficiency (RI), vitamin D deficit and hypomagnesemia.Aim: To identify clinical factors associated with iPTH elevation in patients submitted to surgery treatment.Methods: The medical records of patients admitted into Santo António&#14...

ea0029p378 | Clinical case reports - Pituitary/Adrenal | ICEECE2012

Pregnancy in an acromegalic woman: a case report

Ferreira M. , Palma I. , Caldas A. , Goncalves J. , Pinto C. , Vilaverde J. , Dores J.

Introduction: Acromegaly is a rare disease caused by an increased secretion of GH, usually derived from a benign pituitary tumor. Women with acromegaly are usually infertile, because of tumoral hypersecretion, compression or surgical sequelae. We can prevent infertility with an adequate treatment. There are some reports describing pregnacies among acromegalic women. It is believed that there is an increased risk of develloping diabetes mellitus and hypertension, especially whe...

ea0029p1445 | Pituitary Clinical | ICEECE2012

Pituitary tumor apoplexy: overview of 14 cases diagnosed during the last 12 years at a central hospital

Caldas A. , Ferreira M. , Moreira S. , Ribeiro I. , Cardoso H. , Palma I. , Borges F.

Introduction: Pituitary apoplexy is a potentially life-threatening syndrome due to acute infarction and/or hemorrhage of the pituitary gland. In many cases it is the first form of presentation of a pituitary adenoma. The purpose of the study is to analyze the clinical presentation, diagnosis and treatment of this syndrome.Patients and methods: A retrospective analysis of the patients diagnosed with pituitary tumor apoplexy at Santo Antonio’s Hospita...

ea0056p588 | Obesity | ECE2018

Strength training results in reduced fat accumulation and improved blood lipid profile even in the absence of skeletal muscle hypertrophy in obese rats induced by high-fat diet

Contreiro Catarina , Damiani Andressa , Caldas Leonardo , Nogueira Breno , Leopoldo Andre , Lima-Leopoldo Ana Paula , Guimaraes-Ferreira Lucas

Obesity is a chronic multifactorial disease characterized by accumulation of body fat and is associated with a number of comorbidities, such as diabetes and cardiovascular disease. The treatment of obesity depends to the severity of the disease, however, healthy eating with caloric restriction and physical activity are important strategies. In the present study, we aimed to evaluate the effect of obesity associated with strength training on skeletal muscle morphology, body adi...

ea0073aep251 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Bupropion/naltrexone associated psoriasis in an obese patient

Sara Campos Lopes* , Regina Caldas* , Maria José Guimarães , Areal Joana , Alves Marta , Pereira Teresa

*These authors contributed equally to this workIntroductionThe prevalence of obesity has risen dramatically worldwide in the last three decades. Due to this obesity pandemic, a growing demand for weight-loss drugs has emerged. The increased use of these drugs has consequently lead to an increase in the report of adverse reactions.Case reportA 45-year-old woman with past medical history ...

ea0042p36 | (1) | Androgens2016

Androgen and Estrogen Receptor Co-regulation of Human UDP-glucuronosyltransferases 2B15 and 2B17 in Breast Cancer

Hu Dong Gui , Selth Luke , Tarulli Gerard , Meech Robyn , Wijayakumara Dhilushi , Chanawong Apichaya , Russell Roslin , Caldas Carlos , Robinson Jessica LL , Carroll Jason , Tilley Wayne , Mackenzie Peter , Hickey Theresa

Glucuronidation is an enzymatic process that terminally inactivates steroid hormones, including estrogens and androgens, thereby influencing carcinogenesis in hormone-dependent cancers. While estrogens drive breast carcinogenesis via the estrogen receptor alpha (ERα), androgens play a critical role as prohormones for estrogen biosynthesis and ligands for the androgen receptor (AR). Herein, the expression and regulation of two androgen inactivating UDP-glucuronosyltransfer...

ea0035p769 | Obesity | ECE2014

Relationship of serum TSH with BMI, weight and HOMA-IR in euthyroid obese subjects

Garrido Susana , Caldas Ana Rita , Pereira Teresa , Carvalho Andre , Amaral Claudia , Freitas Claudia , Carvalho Rui , Bravo Fatima , Oliveira Jose Carlos , Cardoso Helena

Introduction: Most obese subjects have a normal thyroid function. Despite that, serum TSH seems to be slightly higher in this population, with a positive correlation with the degree of obesity.Objective: Evaluation of the relationship of serum TSH with BMI, weight, and HOMA-IR in euthyroid obese subjectsMethods: Three hundred obese subjects attending an Obesity Outpatient Clinic and submitted to bariatric surgery between January 20...