Endocrine Abstracts

Background: The Turner Syndrome Life Course Project, UCLH, has collected data on 810 women with TS, attending clinic for 20 years and has accumulated over 8000 clinic visits. We present an analysis of the effects of timing and type of exogenous oestrogen on health outcomes in adults.Methods: A cross- sectional analysis of 475 subjects with primary amenorrhoea with accurate age of pubertal induction data was performed using correlation coefficients contro...

Background: The Turner Syndrome Life Course Project, UCLH, has collected data on 810 women with TS, attending clinic for 20 years and has accumulated over 8000 clinic visits. We present an analysis of the effects of timing and type of exogenous oestrogen on health outcomes in adults.Methods: A cross- sectional analysis of 475 subjects with primary amenorrhoea with accurate age of pubertal induction data was performed using correlation coefficients contro...

Background: The Turner Syndrome Life Course Project, UCLH, has collected data on 810 women with TS, attending clinic for 20 years and has accumulated over 8000 clinic visits. We present an analysis of the effects of timing and type of exogenous oestrogen on health outcomes in adults.Methods: A cross-sectional analysis of 475 subjects with primary amenorrhoea with accurate age of pubertal induction data was performed using correlation coefficients control...

Introduction: Women with Turner syndrome (TS) have an increased risk of diabetes mellitus (DM) the pathogenesis of which is not well understood. International guidelines for TS recommend oral glucose tolerance tests (OGTT) but the utility of this test has not been determined. We sought to establish the rate of IGT and DM and characterise the DM-phenotype in adult women with TS.Methods: We performed OGTTs in 37 adults with TS and obtained an additional fa...

Improvements in circulating cytokine levels have occurred in patients with endometriosis and chronic heart disease when prescribed the type 2 diabetes (T2D) drug metformin. However it is unclear how metformin exerts these effects and whether or not they are related to antihyperglycaemic effects in T2D. The purpose of this study is to investigate the relationship between anti-inflammatory and anti-hyperglycaemic effects of metformin in the liver, the main target tissue of the d...

Introduction: The thorough investigation and prompt management of hypoglycaemia is crucial in determining the diagnosis and preventing associated morbidity and mortality. Delay in obtaining blood samples during the ‘Golden Hour’ of hypoglycaemia, and sampling incorrectly or insufficiently may result in missed diagnosis and necessitates readmission for a fasting glucose profile. This audit was undertaken to evaluate the successful implementation of hypoglycaemia scree...

Introduction: Clinical features of severe headache, vision loss, and papilledema; normal neuroimaging and elevated opening pressure on lumbar puncture are diagnostic of idiopathic intracranial hypertensions (IIH) or pseudotumor cerebri. Etiology is often attributed to obesity in young female patients. We present a rare case of Pseudotumor cerebri in a non-obese female patient with severe hypocalcemia.Case: A 26 year old Hispanic female patient with past ...

Stem cell therapy offers a far-sighted opportunity to cure Type 1 diabetes. To achieve this ambitious goal, an in depth understanding of how human beta cells normally develop is critical, as it provides the perfect model for the differentiation of stem cells down normal safe developmental pathways. Our data provide a framework of human pancreas development and islet formation, highlighting subtle differences from the parallel process in mouse. Key genes have been identified th...

A 56 year old female who attends the general endocrine outpatient appointments for acromegaly secondary to pituitary macroadenoma diagnosed in March 2022. She has a history of breast cancer (HER2+), papillary thyroid cancer and is under active treatment for metastatic non-small cell lung cancer (adenocarcinoma) diagnosed in 2019. Her initial MRI pituitary was performed in March 2022 after an interval scan from oncology to assess disease response to treatment identified a pitui...

Research shows that young people with diabetes often have poor attendance rates in clinical settings and increased presentations of DKA at hospitals. Clinical settings may not adequately support young people in managing all aspects of their diabetes. Engaging young co-researchers in research design, implementation, and dissemination provides invaluable insights into the unique challenges of managing diabetes in adolescence and young adulthood. The D1-Now study aims to be one o...