Searchable abstracts of presentations at key conferences in endocrinology

ea0011p127 | Clinical case reports | ECE2006

Autoimmune hypophysitis causing permanent diabetes insipidus – a case report

Grant D , Campbell K , Connell J

Autoimmune hypophysitis is a rare cause of pituitary failure. ItÂ’s aetiology and natural history are not well understood. We present a case of pituitary failure that showed spontaneous resolution of radiological and clinical features, consistent with autoimmune hypophysitis.Case report: An 18 year old male presented with a 7 month history of polyuria and headaches. No significant past medical history or family history were noted. A water deprivation...

ea0011p749 | Steroids | ECE2006

Hydrocortisone replacement therapy- the controversy continues…

Freel M , Thomson A , Devers M , Campbell K , Grant D , Wallace M , Connell J

Although hydrocortisone is the standard replacement therapy for primary or secondary adrenal insufficiency (AI), there are limited data on dosage requirements and the value of salivary monitoring in this patient group. We assessed inter-individual variability in cortisol metabolism and relationships between plasma and salivary cortisol profiles in 27 patients. Ten (3 male) patients had primary AI and 17 (8 male) secondary AI. Salivary and plasma cortisol levels were measured a...

ea0008p87 | Steroids | SFE2004

Variability in Hydrocortisone Pharmacokinetics Following Intravenous and Oral Administration in Patients with Adrenal Insufficiency

Devers MC , Thomson AH , Freel M , Grant D , Campbell K , Wallace M , Connell JMC

Hydrocortisone is the standard replacement therapy in patients with primary or secondary adrenal insufficiency (AI) but there is no current consensus on the most appropriate replacement dose and the extent to which this varies between individuals. This study examines inter-individual variability in cortisol metabolism in patients taking hydrocortisone therapy and investigates the relationship between plasma and salivary concentrations.Subjects and Method...

ea0003oc9 | Endocrine Neoplasia | BES2002

Breast cancer cells express the vitamin D activating enzyme 1alpha-hydroxylase

Townsend K , Evans K , Hughes S , Mork|#Hansen C , Colston K , Campbell M , Hewison M

Studies in vitro have highlighted the potent anti-cancer effects of the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D3). However, the in vivo application of 1,25D3 and its synthetic analogs remains problematical due to persistent hypercalcaemic side-effects. Recent studies have shown that it may be possible to overcome this in an autocrine fashion via extra-renal synthesis of 1,25D3. In particular, analysis of prostate and co...