Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep75 | Adrenal cortex | ECE2015

Biochemical control and clinical improvement is induced by long-term pasireotide administration in the majority of patients with Cushing's disease persistent after pituitary surgery

Messina Erika , Albani Adriana , Ferrau Francesco , Trimarchi Francesco , Cannavo Salvatore

Pasireotide (SOM230) is a multireceptor ligand somatostatin analogue with high binding affinity to somatostatin receptor subtype 5, which is predominantly expressed in ACTH-secreting pituitary adenomas. It is indicated for the treatment of adult patients with Cushing’s disease (CD) for whom pituitary surgery is not an option or has not been curative. Our study evaluated the effects of pasireotide, administered for 12 months at a dose of 600–900 μg/daily, in five...

ea0081p738 | Thyroid | ECE2022

Predictors of associated autoimmune diseases in patients with Hashimoto′s thyroiditis.

Ruggeri Rosaria , Trunfio Francesca , Giuffrida Giuseppe , Trimarchi Francesco , Campenni Alfredo , Cannavo Salvatore

Background: Increased rates of autoimmune diseases (ADs) have been reported in association with Hashimoto′s thyroiditis (HT); however, the risk factors for coexisting ADs in HT patients have been poorly investigated.Objective: To evaluate the prevalence and factors associated with AD comorbidities in patients with HT.Materials and Methods: We recruited 687 patients (626 F and 61 M, mean age at diagnosis 39 ± 14.06 yr, F:...

ea0063gp178 | Benign Thyroid Disorders | ECE2019

Cystic fibrosis as a novel cause of thyroxine (l-t4) malabsorption and increased requirement

Giuffrida Giuseppe , Magazzu Giuseppe , Campenni Alfredo , Lucanto Maria Cristina , Trimarchi Francesco , Cannavo Salvatore , Ruggeri Rosaria Maddalena

Background: Cystic fibrosis (CF), a monogenic disease from mutations in the CFTR gene on chromosome 7, causes pancreatic insufficiency and impaired nutrients absorption. Unlike other malabsorption disorders, no data are available in literature on L-T4 absorption in CF. This study analyzed L-T4 absorption and requirement in hypothyroid CF patients.Methods: Ten CF patients (7 F, 3 M; mean age 37 yr), with autoimmune (n=6) or post-thyroidectomy (<e...

ea0063gp239 | Anterior and Posterior Pituitary | ECE2019

Peptide receptor radionuclide therapy (PRRT) in patients with giant aggressive pituitary tumors: experience of an Italian referral center and review of literature

Giuffrida Giuseppe , Ferrau Francesco , Laudicella Riccardo , Cotta Oana Ruxandra , Vento Antonio , Baldari Sergio , Cannavo Salvatore

Background: Pituitary tumours (PT) are generally benign, but they can rarely show an aggressive behaviour, invade surrounding structures and/or grow/recur despite multimodal treatment, making their management extremely challenging. According to the latest guidelines, temozolomide (TMZ) can be an option after failure of standard therapies in aggressive PT, while little data are available on alternative approaches such as peptide receptor radionuclide therapy (PRRT). Herein we r...

ea0037ep53 | Adrenal cortex | ECE2015

Beneficial effects of replacement therapy with modified-release hydrocortisone in patients with adrenal insufficiency

Morelli Valentina , Messina Erika , Mendola Marco , Cairoli Elisa , Ambrosi Bruno , Cannavo Salvatore , Chiodini Iacopo , Spada Anna

Introduction: The classical replacement therapy for hypoadrenalism may expose patients to non-physiologic glucocorticoids levels with negative metabolic consequences. Up to now, one study demonstrated that, as compared to the classical treatment, a modified-release hydrocortisone (MRH), improves weight, blood pressure, glycaemic control and QoL in a 3-month follow-up period. Few data are available on the long-term persistence of these benefits.Design/met...

ea0016p455 | Neuroendocrinology | ECE2008

Systemic comorbidities induce early vascular alterations in patients with active acromegaly

Ferrau Francesco , Romanello Giovanni , Squadrito Stefano , Carerj Scipione , Nipote Carmelo , Iudicello Raffaella , Trimarchi Francesco , Cannavo Salvatore

Mortality risk is increased in acromegalics, due to cerebrovascular and cardiovascular events. These events are namely related to atherosclerotic vascular alterations, both at coronary and peripheral level. Systemic comorbidities increase the risk of atherosclerosis, but the role of GH and IGF-1 excess is still debated. To evaluate the relationship between GH/IGF-1 excess, systemic atherogenic complications and vascular alterations we investigated stiffness index (β), pul...

ea0056p189 | Bone ' Osteoporosis | ECE2018

Novel heterozygous mutation of tissue-non-specific alkaline phosphatase (TNSALP) gene causing late-onset hypophosphatasia

Ruggeri Rosaria Maddalena , Certo Rosaria , Guarnieri Vito , Giovinazzo Salvatore , Ferrau Francesco , Cannavo Salvatore

Background: Hypophosphatasia (HPP) is a rare metabolic, inherited disease of bone metabolism, caused by loss-of-function mutations within the gene coding for TNSALP, that result in a decrease in serum ALP concentrations and consequent accumulation of ALP substrates outside of the cell, including inorganic pyrophosphate which inhibits bone mineralization. HPP leads to a variety of clinical manifestations across all ages and its prognosis is conditioned principally by the skelet...

ea0084ps2-06-56 | Hypothyroidism Treatment | ETA2022

Polychlorinated biphenyl congeners PCB 118 and PCB 126 induce upregulation PD-L1 expression in human thyrocytes through aryl hydrocarbon receptor (AHR) pathways

Ruggeri Rosaria , Minuti Aurelio , Aliquo Federica , Giani Fiorenza , Campenni Alfredo , Trimarchi Francesco , D'Ascola Angela , Cannavo Salvatore

Objective: Polychlorinated biphenyls (PCBs) are persistent organic pollutants that that have been reported to cause a variety of toxic effects, including inflammation and cancer, through binding to the aryl hydrocarbon receptor (AhR). In turn, AhR promotes xenobiotic detoxification and antioxidant defense, by up-regulating specific responsive genes, the so-called “AhR gene battery”. AhR is also involved in modulation of immune response, by regulating programmed cell ...

ea0081p742 | Thyroid | ECE2022

Curcumin attenuates the pro-inflammatory response induced by hyaluronan oligosaccharides in human thyroid fibroblasts and thyrocytes

Ruggeri Rosaria , Minuti Aurelio , Aliquo Federica , Campenni Alfredo , Avenoso Angela , Giani Fiorenza , Masto Roberta , Cannavo Salvatore , D'Ascola Angela

Background: Lymphocytic infiltration and inflammation in autoimmune thyroid diseases (AITDs) results in accumulation of HA, contributing to the pathogenesis of both thyroidal and extra-thyroidal (ophthalmopathy, pretibial dermopathy and mixedema) manifestations of AITDs. HA fragments, originating from native HA during tissue inflammation and injury, in turn promote the expression of different mediators of oxidative stress and inflammation, by interacting with the Toll-like rec...

ea0081ep702 | Pituitary and Neuroendocrinology | ECE2022

Giant pituitary adenomas in children and adolescents: clinical presentation, management and long-term outcome

Giuffrida Giuseppe , giovinazzo salvatore , Alessi Ylenia , Ragonese Marta , Cotta Oana Ruxandra , Angileri Filippo Flavio , Ferrau Francesco , Cannavo Salvatore

Background: Pituitary adenomas in children/adolescents represent around 3% of all intracranial neoplasms. They are more frequently hormone-secreting lesions, usually diagnosed in early childhood and late adolescence. Female gender is generally prevalent, because of most evident symptoms (i.e., irregular periods, galactorrhea, etc.). Giant pituitary adenomas (GA) very rarely occur in pediatric age, posing frequent challenges in their management.Patients a...