Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep988 | Thyroid (non-cancer) | ECE2015

Levothyroxine therapy in comparison: fixed vs alternating dosage in subclinical hypothyroidism

Pastore Renato , Cannuccia Amalia , Simona Frontoni

Introduction: Oral levothyroxine (L-T4) is the standard treatment for hypothyroidism and serum TSH represents the best marker for assessing the proper L-T4 dose. The absorption and bioequivalence of different commercial L-T4 preparations might be variable. The aim of this study is to compare the efficacy of L-T4 using alternating doses vs fixed ones.Me...

ea0059p010 | Adrenal and steroids | SFEBES2018

Exploring the utility of renin measurements in the routine management of salt-wasting congenital adrenal hyperplasia

Pofi Riccardo , Cannuccia Amalia , Lenzi Andrea , Isidori Andrea M , Tomlinson Jeremy W

The importance of measuring renin or plasma renin activity (PRA) and aldosterone in establishing mineralocorticoid deficiency is not in doubt. Once mineralocorticoid replacement therapy is initiated, guidance suggests that optimization of mineralocorticoid dose should be based upon measurements of blood pressure, renin (or PRA), and electrolytes. The aim of this study was to explore the relationship between renin and clinically important variables to determine whether measurem...

ea0063gp197 | Adrenal and Neuroendocrine - Clinical | ECE2019

Optimizing mineralocorticoid replacement therapy in patients with congenital adrenal hyperplasia and Addison’s disease

Pofi Riccardo , Prete Alessandro , Thornton-Jones Vivien , Bryce Jilian , Ali Salma , Ahmed Faisal , Koehler Birgit , Balsamo Antonio , Acerini Carlo , Cannuccia Amalia , Guven Ayla , Guran Tulay , Darendeliler Feyza , Higham Claire , Bonfig Walter , De Vries Liat , Mendonca Berenice B , Iotova Violeta , Krone Nils P , Krone Ruth , Lenzi Andrea , Arlt Wiebke , Ross Richard , Isidori Andrea M , Tomlinson Jeremy W

Background: Adrenal insufficiency (AI) results from deficient production/action of glucocorticoids (GCs), with or without deficiency of mineralocorticoids (MC) and adrenal androgens. GC treatment is essential but some patient needs MC therapy to allow sodium(Na+) retention, potassium(K+) excretion and to maintain normal plasma volume and blood pressure. Much attention has focused on optimization of GC replacement but no consensus exists for optimization o...