Searchable abstracts of presentations at key conferences in endocrinology

ea0040l13 | Cellular and animal models in Pheochromocytoma/Paragangliomas research: Role of microenvironment | ESEBEC2016

Cellular and animal models in pheochromocytoma/paragangliomas research: role of microenvironment

Mannelli M , Rapizzi E , Canu L , Ercolino T , Giache V

Pheochromocytomas (PHEOs) and paragangliomas (PGLs) are rare neuroendocrine tumors. About 30-40% of these tumors are due to e germ-line mutation in one of the 13 main susceptibility genes which include: the tumor-suppressor gene VHL; the proto-oncogene RET; the tumor-suppressor gene Nf1; the genes encoding the four subunits of the succinate dehydrogenase (SDH); the SDHAF2/SDH5 gene that is responsible for the flavination of the SDHA subunit;...

ea0026p362 | Adrenal medulla | ECE2011

Succinate dehydrogenase (SDH) mutations: biochemical and functional effects in pheochromocytoma/paraganglioma tissues

Rapizzi E , Ercolino T , Canu L , Giache V , Mannelli M

Pheochromocytoma (PHEO)/paraganglioma (PGL) are neural crest-derived tumors, and about 25% of the apparently sporadic cases are due to a germ line mutation in one of the susceptibility genes. The group of these genes includes the genes encoding three of the four subunits of the SDH, and the recently discovered gene, SDHAF2/SDH5, responsible for the flavination of the SDHA subunit.Although several hypotheses have been proposed, the molecular events by whi...

ea0026p4 | Adrenal cortex | ECE2011

Effects and kinetics of mitotane in in vitro and in vivo models of adrenocortical carcinoma

Luconi M , Poli G , Mangoni M , Pezzati P , Francalanci M , Gelmini S , Canu L , Cantini G , Serio M , Mannelli M

Adrenocortical carcinoma (ACC) is a rare aggressive tumor with a poor prognosis. At present, early diagnosis followed by total surgical tumor resection is the only valuable option for ACC cure and mitotane (MTT) is the only specific drug available for pharmacological treatment. However, its effects seem to be mainly due to its adrenocortical cytotoxicity and its bioavailability and cellular mechanism of action are still unknown, making it difficult to develop less toxic multid...

ea0029p102 | Adrenal cortex | ICEECE2012

Proteomic approach to human adrenocortical cancer biology

Poli G. , Ceni E. , Michelucci E. , Canu L. , Piccini V. , Nesi G. , Cantini G. , Moneti G. , Galli A. , Mannelli M. , Luconi M.

Adrenocortical carcinoma (ACC) is a rare tumor with poor prognosis due to its highly malignant phenotype and lack of effective treatment options.The etiology of ACC is still unknown. To better understand the pathogenesis of this type of tumor and to determine differentially abundant proteins and candidate biomarkers for adrenal cancer diagnosis and prognosis, we used a novel approach based on two-dimensional differential gel electrophoresis (2D-DIGE). Pr...

ea0056gp45 | Adrenal medulla and NETs | ECE2018

The 10 Hounsfield Units cut-off value on unenhanced CT imaging is highly sensitive to diagnose pheochromocytoma: a multicenter study

Buitenwerf E , Korteweg T , Haag MSC , Feelders RA , Timmers HJLM , Canu L , Haak HR , Bisschop PHLT , Eekhoff EMW , Corssmit EPM , Dullaart RPF , Links TP , Kerstens MN

Introduction: A substantial proportion of pheochromocytomas (PCC) are detected during the work-up of an adrenal incidentaloma. Recently it has been suggested that in case of an adrenal incidentaloma with an unenhanced attenuation value <10 Hounsfield Units (HU) on CT imaging biochemical testing to rule out PCC is unnecessary. We aimed to determine the sensitivity of the 10 HU cut-off value to detect pheochromocytoma.Methods: Retrospective multicenter...