Searchable abstracts of presentations at key conferences in endocrinology

ea0070oc5.3 | Thyroid | ECE2020

Acute pancreatitis associated with methimazole treatment: A retrospective analysis of administrative health databases conducted in the Piedmont Region, Italy

Caputo Marina , Pecere Alessandro , Sarro Andrea , Zibetti Angelica , Marzullo Paolo , Aimaretti Gianluca , Barone-Adesi Francesco

Purpose: Methimazole (MMI) is a widely used antithyroid agent for first-line treatment of hyperthyroidism. A warning has been recently issued by the European Medicine Agency (EMA) regarding a potential increased risk of acute pancreatitis (AP) in MMI users, based on evidences from published case reports and post-marketing surveillance. The aim of this study was to investigate the association between MMI treatment and the diagnosis of AP in drug users.Mat...

ea0022p421 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Thyroid Incidentaloma identified by 18F-Fluorodeoxyglucose Positron Emission Tomography with CT (FDG-PET/CT): clinical relevance

Pagano Loredana , Sama MariaTeresa , Rudoni Marco , Belcastro Sara , Busti Arianna , Caputo Marina , Inglese Eugenio , Aimaretti Gianluca

Thyroid incidentalomas was defined as newly identified thyroid lesions encountered during imaging study for non-thyroid diseases. In the last years, the use of FDG-PET/CT for staging of metastatic diseases was increased. The aim of this retrospective study was to evaluate the FDG-PET/CT uptake, to identify a SUVmax cut off predictive of malignancy and to determine the FDG-PET/CT prognostic role in patients with thyroid incidentalomas. 42 patients (ptx) with incidental thyroid ...

ea0073aep201 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Liraglutide for weight management in syndromic obesity: effects in overgrowth adult Beckwith–Wiedemann syndrome

Caputo Marina , Daffara Tommaso , Bellone Simonetta , Mancioppi Valentina , Marzullo Paolo , Aimaretti Gianluca , Prodam Flavia

ContextGenetic obesity, including syndromic and non-syndromic forms, represent a minority of cases but gene dysregulations make their management particularly difficult. Among them, Beckwith–Wiedemann syndrome (BWS) is a multisystem human genomic imprinting disorder characterized by overgrowth, macroglossia, abdominal wall defects, hemi hyperplasia, enlarged abdominal organs, and an increased risk of embryonal tumours. The syndrome is caused by genet...

ea0081ep569 | Endocrine-Related Cancer | ECE2022

Novel pathogenetic mutation of MEN1 gene causing hyperparathyroidism, pancreatic glucagonoma, adrenal adenoma, and collagenomas

Pitino Rosa , Vimercati Davide , Pizzolitto Francesca , Mollero Edoardo Luigi Maria , Daffara Tommaso , Ferrero Alice , Boldorini Renzo , Caputo Marina , Prodam Flavia

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary autosomal dominant tumor syndrome caused by inactivating mutations of the tumor suppressor gene MEN1 which encodes the protein menin. It is characterized by the occurrence of tumors involving two or more endocrine glands, primarily parathyroid, entero-pancreatic, and anterior pituitary, as well as non-endocrine neoplasms. Glucagonomas occur in fewer than 3% of patients with MEN1, causing hyper...

ea0032p467 | Diabetes | ECE2013

Efficacy and safety of 1 year treatment with Liraglutide in subjects with type 2 diabetes

Prodam Flavia , Zavattaro Marco , Ponziani Chantal , Pagano Loredana , Caputo Marina , Allochis Gabriele , Teresa Sama Maria , Busti Arianna , Aimaretti Gianluca

Introduction: Liraglutide, a GLP-1 analogue, is a new option for the treatment of type 2 diabetes (DM2). The purpose of this study was to evaluate the efficacy and safety of liraglutide in daily clinical practice in a heterogeneous population with DM2.Subjects and methods: Four visits were scheduled in a 1 year study (baseline, 4, 8 and 12 months). All patients with a HbA1c not on target (>7%) during an oral hypoglycemic treatment, or patients intole...

ea0032p473 | Diabetes | ECE2013

Cardiovascular effects of treatment with Liraglutide in a population with type 2 diabetes

Zavattaro Marco , Prodam Flavia , Grazia Mauri Maria , Pagano Loredana , Caputo Marina , Belcastro Sara , Allochis Gabriele , Aimaretti Gianluca

Introduction: Liraglutide, a human GLP-1 analogue, is a new option for the treatment of type 2 diabetes (DM2). The purpose of this study was to evaluate the effects of liraglutide on cardiovascular risk factors in daily clinical practice in a heterogeneous population with DM2.Subjects and methods: Four visits were scheduled in a 1 year study (baseline, 4, 8 and 12 months). Patients with a HbA1c not on target (>7%) during an oral hypoglycemic treatmen...

ea0056p616 | Neuroendocrinology | ECE2018

Use of a new classification algorithm based on administrative health databases to estimate incidence and prevalence of acromegaly in Piedmont Region, Italy

Caputo Marina , Ucciero Andrealuna , Mele Chiara , De Marchi Lucrezia , Magnani Corrado , Marzullo Paolo , Barone-Adesi Francesco , Aimaretti Gianluca

Background and aim: Information on incidence and prevalence of acromegaly usually originates from studies performed in referral endocrine care centers, whose catchment areas do not generally cover the entire population. Administrative databases can provide key information to assess the impact of acromegaly on patients and health systems. Our study aimed at estimating the prevalence and incidence data of acromegaly stratified by age and sex using data obtained in the Piedmont r...

ea0073pep12.6 | Presented ePosters 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Serum leptin and urine cortisol to cortisone ratio are correlated in familiar partial lipodystrophy type I (Kobberling Syndrome)

Daffara Tommaso , Mancioppi Valentina , Caputo Marina , Leone Ilaria , Ferrero Alice , Pelosini Caterina , Santini Ferruccio , Aimaretti Gianluca , Ceccarini Giovanni , Prodam Flavia

BackgroundIn lipodystrophy (LD) adipose tissue function is impaired, leading to a severe metabolic syndrome. Familiar Partial LD (FPLD) type I (Kobberling Syndrome) overlaps with Cushing’s syndrome phenotype. The latter and the metabolic impairment observed in FPLD1 may suggest a crosstalk between the HPA axis, assuming that leptin sensitivity is preserved in this context. We aimed to evaluate if leptin levels are associated with glucocorticoid acti...

ea0081rc1.2 | Rapid Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2022

Glucose alterations, insulin resistance, hypertension, and activation of the renin-aldosterone system are strictly associated in pediatric obesity

Antoniotti Valentina , Amore Martina , Bellone Simonetta , Ricotti Roberta , De Grandi Roberta , Caputo Marina , Spadaccini Daniele , Mancioppi Valentina , Aimaretti Gianluca , Prodam Flavia

Background: The increase of global childhood obesity has led to an increase of associated co-morbidities also at a young age. The pro-inflammatory state and insulin resistance are two master regulators of several complications, including hypertension and pre-diabetes frequently connected in a complex cross-talk.Aim: To evaluate the relationship between glucose alterations and blood pressure and the pathogenetic involvement of the renin-aldosterone system...

ea0081p602 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Mediterranean Diet and 12 months weight loss result in complex serum metabolomic and fecal metaproteomic changes in paediatric obesity

Spadaccini Daniele , Vita Vanella Virginia , Barberis Elettra , Ricotti Roberta , Bellone Simonetta , Bona Elisa , Antoniotti Valentina , Caputo Marina , Mancioppi Valentina , Rabbone Ivana , Manfredi Marcello , Prodam Flavia

Background: The relationship between composition and function of microbiota, obesity and nutrition has been increasingly studied and is still a challenge.Aims: To test whether in a group of 12 pediatric patients with obesity the treatment with a structured hospital and in-home Mediterranean Diet intervention had an impact on gut microbiota composition, function, and metabolite production, including Short chain fatty acids (SCFAs).M...