Searchable abstracts of presentations at key conferences in endocrinology

ea0029p623 | Diabetes | ICEECE2012

Effects of chronic administration of Vardenafil on endothelial function in patients with type 2 diabetes mellitus. A longitudinal, randomized, placebo-controlled, double blind, non-sponsored clinical trial

Santi D. , Guidi A. , Granata A. , Simoni M. , Carani C.

Introduction: The endothelium produces molecules regulating vascular function, such as nitric oxide (NO). NO protects blood vessels from endogenous injury and causes vasodilation through activation of second messengers. In diabetes mellitus (DM), hyperglycemia provokes oxidative stress, reduction of NO and increased synthesis of vasoconstrictors (e.g. endothelin). Cyclic nucleotide phosphodiesterases (PDEs) are enzymes, controlling the rate of degradation of second messengers....

ea0029p1010 | Male Reproduction | ICEECE2012

Prevalence of olfactory and other developmental anomalies in patients with central hypogonadotropic hypogonadism

Valle E. Della , Vezzani S. , Rochira V. , Granata A. , Carani C. , Genovese E. , Simoni M.

Introduction: Hypogonadotropic hypogonadism (HH) is a heterogenous disease caused by mutations in several genes. Based on the presence of hyposmia/anosmia it is distinguished into Kallmann syndrome and isolated HH. The prevalence of other developmental anomalies is not well established.Methods: We studied patients with HH (29 males, 3 females, mean age 41.5), 9 with familial and 23 sporadic HH (29 congenital, 3 adult-onset), by physical examination, smel...

ea0029p1549 | Steroid metabolism + action | ICEECE2012

The cellular fate of CYP19A1 (aromatase) protein

Pignatti E. , Ferioli S. , Carani C. , Rochira V. , Poti F. , Simoni M.

Introduction: Aromatase cytochrome P450 is uniquely responsible for estrogen synthesis in vertebrates. The protein is expressed in the gonads and other extraglandular tissues. Deregulated expression of aromatase has pathological relevance and targeting the CYP19A1 product could be an effective strategy for treatment of affected tissues. Nevertheless, very little is known concerning the role of protein oligomerisation, glycosylation and degradation. Here we studied the aromatas...

ea0029p1764 | Thyroid cancer | ICEECE2012

Value of repeated US-guided fine-needle aspirations (US-FNAB) in the follow-up of thyroid nodules: the MoCyThy (Modena’s Cytology of the Thyroid) DATABASE

Ansaloni A. , Belli S. , Vezzani S. , Granata A. , Zirilli L. , Cioni K. , Carani C. , Madeo B. , Rochira V.

Introduction: There is no consensus about the usefulness of repeating the US-FNAB during the follow-up of nodules when a benign (Thy2) or indeterminate (Thy3) report is obtained at first US-FNAB.Aim of the study: To investigate the clinical value of repeating US-FNAB after a previous adequate Thy2 or Thy3 US-FNAB.Methods: We reviewed the US-FNABs performed from 2006 to 2009. All clinical data of the patients were collected and anal...

ea0029p1771 | Thyroid cancer | ICEECE2012

Ultrasound (US) features of thyroid nodules with cytology suspicious for malignancy

Taliani E. , Ansaloni A. , Diazzi C. , Granata A. , Carani C. , Rochira V. , Madeo B.

Introduction: Several studies in literature have shown that some features of thyroid nodules at US are associated with malignancy. However, previous studies were focused mainly on subjects affected by multinodular goiter (about 70%) rather than subjects with thyroid cancer (about 30%). Furthermore, the main limitation of previous studies was the lack of thyroidectomy in all subjects.Aim of the study: To evaluate the diagnostic value of US features in a s...

ea0029p1772 | Thyroid cancer | ICEECE2012

Incidence of ultrasound thyroid scan anomalies in healthy volunteers in modena, italy

Gnarini V. , Brigante G. , Della Valle E. , Taliani E. , Carani C. , Simoni M.

Introduction: We assessed the incidence of ultrasound (US) thyroid scan anomalies in adult volunteers in the district of ModenaMethods: From December 2010 to October 2011 we performed US thyroid scan (Siemens Acuson Antares, 10 Mega Hertz-Linear scanner- B mode) in a cohort of 201 volunteers, recruited by local advertisement, women (n=135) and men (n=66), mean age 46±10.7. All participants were unaware of any thyroid disease and at the...

ea0026p23 | Adrenal cortex | ECE2011

Multicenter study on the prevalence of sexual symptoms in men affected by Addison disease

Granata A , Pugni V , Arnaldi G , Guidi A , Santi D , Balercia G , Carani C

Introduction: Male sexual behaviour is deeply influenced by the endocrine system. However, few data are available on low cortisol serum levels and sexuality.Subjects and methods: In order to investigate the sexual function in 12 men before and during replacement treatment for Addison disease (AD), we performed sexual and psychological evaluations before replacement therapy (‘baseline’) and at least 8 weeks after complete recovery from cortisol ...

ea0026p153 | Male reproduction | ECE2011

Lower serum testosterone and estradiol (E2) in adult men with unfused epiphyses due to unrecognized and untreated congenital hypogonadotropic hypogonadism: evidence for an E2 threshold for bone maturation in men

Rochira V , Balestrieri A , Zirilli L , Madeo B , Sgarbi I , Luberto A , Carani C

Introduction: At puberty, the raise of serum estradiol (E2) (after testosterone conversion) is needed to fuse ephiphyses and to complete bone maturation in boys. Owing to severe hypogonadism and very low circulating testosterone, adult men with congenital hypogonadotropic hypogonadism (CHH) may present with unfused epiphyses and continuing linear growth if androgen deficiency is unrecognized and untreated. In order to establish the minimal amount of sex steroids nee...

ea0026p452 | Thyroid cancer | ECE2011

Thyroid disease in patients with type-1 neurofibromatosis: an underestimated issue?

Diazzi C , Guidi A , Luberto A , Taliani E , Madeo B , Rochira V , Carani C

Introduction: In type-1 neurofibromatosis (NF-1) there is an increased risk of endocrine tumors, especially pheochromocytomas, whereas thyroid carcinomas seem to be extremely rare, with few cases reported in literature.Subjects and methods: In order to investigate the frequency of hypercalcitoninaemia and medullary thyroid cancer (MTC) in patients with NF-1, we evaluated the thyroid gland morphology and function in 17 patients with NF-1 by i) neck US, ii...

ea0029p1755 | Thyroid cancer | ICEECE2012

The TRHR gene is associated to hypothalamo-pituitary sensitivity to levothyroxine in thyroidectomized patients

Brigante G , Spaggiari G , Cioni K , Gnarini V , Pignatti E , Casarini L , Marino M , Tuttelmann F , Carani C , Simoni M

Background: Patients thyroidectomized for thyroid cancer need variable doses of levothyroxine (LT4) to obtain TSH suppression. A predetermined thyroid function set-point for each individual has been hypothesized, suggesting a genetic influence in the regulation of pituitary-thyroid axis. We hypothesized of the TRHR gene could be associated with a different hypothalamo-pituitary sensitivity to the negative feedback of the thyroid hormones.<p class=...