Searchable abstracts of presentations at key conferences in endocrinology

ea0029p431 | Clinical case reports - Thyroid/Others | ICEECE2012

Impact of glibenclamide therapy in a patient with neonatal diabetes and intermediate DEND syndrome with the V59M mutation in the KCNJ11 gene

Giestas A. , Borges T. , Oliveira M. , Guimaraes A. , Cardoso H.

Introduction: Neonatal diabetes is a rare condition diagnosed within the first months of life. Activating mutation of KCNJ11, the gene encoding the Ki6.2 subunit of the ATP-sensitive potassium channel, is the most common cause of permanent neonatal diabetes, and ~20% of patients have neurological features.Patients with the severe neurological phenotype exhibit developmental delay, motor weakness, and epilepsy in addition to diabetes (DEND syndrome). Inte...

ea0029p1445 | Pituitary Clinical | ICEECE2012

Pituitary tumor apoplexy: overview of 14 cases diagnosed during the last 12 years at a central hospital

Caldas A. , Ferreira M. , Moreira S. , Ribeiro I. , Cardoso H. , Palma I. , Borges F.

Introduction: Pituitary apoplexy is a potentially life-threatening syndrome due to acute infarction and/or hemorrhage of the pituitary gland. In many cases it is the first form of presentation of a pituitary adenoma. The purpose of the study is to analyze the clinical presentation, diagnosis and treatment of this syndrome.Patients and methods: A retrospective analysis of the patients diagnosed with pituitary tumor apoplexy at Santo Antonio’s Hospita...

ea0002p79 | Reproduction | SFE2001


Monteiro M , Cardoso H , Vargas G , Mendes P , Sergio A , Santos M , Santos C , Ramos H

Objectives: To evaluate changes in gonadotrophins, total (TT) and free (FT) testosterone, SHBG, insulin and c-peptide levels during weight lost after bariatric surgery.Material and methods: Seven (n=7) patients submitted to bariatric surgery for treatment of severe obesity were followed-up over time. Before surgery mean age was 32,857 (19-56) years old, mean weight was 170,571 kg (± 37,362) and mean BMI was 58,824 kg per m2(± 14,...

ea0004p63 | Endocrine tumours and neoplasia | SFE2002

Asymptomatic neuroendocrine pancreatic tumours associated with Multiple Endocrine Neoplasia type 1: what to do?

Monteiro M , Carvalho R , Cavaco B , Cardoso H , Castro R , Santos M , Costa M , Correia M , Ramos H

Background: The screening of patients and relatives for the presence of inactivating mutations of the MEN 1 gene, established quite accurately those for prospective detection of neoplasms. Active search for pancreatic lesions has increased the detection of neuroendocrine pancreatic tumours (NEPT) at early ages, most asymptomatic and with no signs of malignancy at diagnosis.Case Report: We describe one kindred where five members were identified as carrier...

ea0003p224 | Reproduction | BES2002

Improvement of hyperandrogenism and insulin resistance in females with severe obesity after weight loss through bariatric surgery

Monteiro M , Cardoso H , Vargas G , Pichel F , Pereira I , Sergio A , Santos M , Bravo F , Santos C , Ramos H

The association of hyperandrogenism and insulin resistance is common in several syndromes. The proposed mechanism is the stimulation of ovarian theca cells by insulin to produce testosterone. Weight loss, improves insulin resistance, reduces insulin levels and consequently decreases circulating androgens.Material and methods:Ten female subjects with severe obesity and hyperandrogenism were evaluated before and after weight loss at...