Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep712 | Male Reproduction | ECE2016

The role of dopamine pathway on human sperm: in vitro effect of dopamine receptor agonists and antagonists on sperm motility, kinetics and viability

de Angelis Cristina , Cariati Federica , Galdiero Giacomo , Coppola Giorgio , Galdiero Mariano , Salzano Ciro , Pivonello Claudia , Patalano Roberta , Alviggi Carlo , De Placido Giuseppe , Colao Annamaria , Pivonello Rosario

Dopamine has been found in both semen and oviductal fluid and dopamine receptors (DRs) have been detected in male genital tract and spermatozoa, suggesting that dopamine system may control important reproductive functions in humans. Dopamine improves sperm motility and viability in animal models, although the underlying molecular mechanisms have not been fully elucidated. The aims of this study were to investigate DRs expression in human spermatozoa and to evaluate the in ...

ea0035p865 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Effect of chronic treatment with cabergoline and testosterone replacement on metabolic parameters in male patients with prolactinomas and hypogonadism

Galdiero Mariano , Auriemma Renata S , Vitale Pasquale , Calzo Fabio Lo , Salzano Ciro , Ferreri Lucia , Cariati Federica , Coppola Giorgio , Colao Annamaria , Pivonello Rosario

Generously supported by IPSEN)-->Hyperprolactinemia is reportedly associated with impaired metabolic profile, particularly in patients with concomitant hypogonadism. The current study aimed at investigating the effects of 12 and 24 month-continuous cabergoline (CAB) treatment on metabolic profile in male hyperprolactinemic patients. Thirty-two men with prolactinomas, including 22 with testosterone < 8 nmol/l (HG, 69%) and 10 with...

ea0032p654 | Male reproduction | ECE2013

Identification of vitamin D (VDR) and retinoic X (RXR) receptor in normal and neoplastic human reproductive tissues

Cariati Federica , Gigantino Vincenzo , Coppola Giorgio , Pivonello Claudia , Galdiero Mariano , Botti Gerardo , Gandini Loredana , Lenzi Andrea , Franco Renato , Colao Annamaria , Pivonello Rosario

Background: Vitamin D is an important modulator of cell growth, differentiation and death in normal and neoplastic cells. Its actions are mediated by vitamin D receptor (VDR), which heterodimerizes with nuclear retinoid X receptors (RXRα). Recently, it has been suggested that vitamin D system have a role in male reproduction. The aim of this study was to investigate the VDR and RXRα localization in normal and neoplastic human male reproductive tissues.<p class="a...

ea0032p891 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Role of reversal of hypogonadism on the improvement of metabolic syndrome in male patients with hyperprolactinemia during chronic treatment with cabergoline

Galdiero Mariano , Auriemma Renata S , Calzo Fabio Lo , Vitale Pasquale , Pivonello Claudia , Cariati Federica , Perone Ylenia , Salzano Ciro , Colao Annamaria , Pivonello Rosario

Introduction: Generously supported by IPSEN)-->Hyperprolactinemia (HPRL) is associated with an impaired metabolic profile, particularly in patients with hypogonadism. This study aimed to: i) investigate the effects of short and long treatment with cabergoline (CAB) on the prevalence of metabolic syndrome (MS) and insulin sensitivity and ii) to evaluate the impact of gonadal function on metabolic changes, in male patients with HPRL.</...

ea0026p74 | Endocrine tumours and neoplasia | ECE2011

In vitro effect of the somatostatin analogue BIM 23704 on cell cycle timecourse in an ovarian carcinoma cell line

de Angelis Cristina , Pivonello Claudia , Cuomo Gaia , Sardo Attilio di Spiezio , Bifulco Guiseppe , Nappi Carmine , Sabbatino Francesco , Cariati Federica , Colao Annamaria , Pivonello Rosario

Ovarian carcinoma (OC) is associated with poor prognosis and low survival rate. Eligible treatment for advanced OC is surgery followed by chemotherapy based on a combination of Platinum and Taxol, but unfortunately long-term outcome of such therapy is disappointing. Moreover, systemic administration of cytotoxic agents is usually accompanied by a series of side effects. On the basis of this evidence, more selective and tumour cell-targeted therapeutic approaches are warranted....