ea0015p148 | Diabetes, metabolism and cardiovascular | SFEBES2008
, Paddon Carol
, Grennan-Jones Fiona
, Ludgate Marian
TSH receptor (TSHR) expression increases >100-fold during adipogenesis and signals via CREB. Since CREB activation has been reported to be necessary and sufficient to induce adipogenesis, we investigated whether TSHR activation, a feature of most thyroid dysfunction, has a role in adipocyte biology and evaluated the contribution of Gsα and Gβγ signalling.Retroviral vectors for WT or constitutively active mutant TSHR* or ...