Searchable abstracts of presentations at key conferences in endocrinology

ea0015p148 | Diabetes, metabolism and cardiovascular | SFEBES2008

Thyrotropin receptor activation and preadipocyte biology; dissecting the effects of Gsα and Gβγ signalling on 3T3-L1 preadipocytes

Zhang Lei , Paddon Carol , Grennan-Jones Fiona , Ludgate Marian

TSH receptor (TSHR) expression increases >100-fold during adipogenesis and signals via CREB. Since CREB activation has been reported to be ‘necessary and sufficient to induce adipogenesis’, we investigated whether TSHR activation, a feature of most thyroid dysfunction, has a role in adipocyte biology and evaluated the contribution of Gsα and Gβγ signalling.Retroviral vectors for WT or constitutively active mutant TSHR* or ...