Searchable abstracts of presentations at key conferences in endocrinology

ea0011p433 | Endocrine disruptors | ECE2006

A randomized, open-label, multicenter study to evaluate octreotide LAR with surgical therapy as primary therapy patients with acromegaly

Colao A , Bouterfa H , Cappabianca P , Caron P , De Menis E , Farrall A , Gadelha M , Reed A , Reincke M , Safari M , T’Sjoen G , Cuneo R

This is the first prospective study to compare the efficacy and safety of medical therapy and surgery as primary therapy in acromegaly.A total of 104 patients with untreated acromegaly were enrolled. Eighty-one patients randomized to receive either octreotide LAR 20 mg (n=40) or surgery (n=41) completed the 48 weeks treatment period, and constituted the population used for this analysis, regardless of response to treatment.<p class="abs...

ea0011p499 | Endocrine tumours and neoplasia | ECE2006

Long-term somatostatin analog octreotide treatment in insulinoma patients

Vezzosi D , Bennet A , Courbon F , Caron P

The usefulness of long-term medical treatment with somatostatin analogs has not been evaluated in insulinomas. 22 patients with hypoglycaemia related to endogenous hyperinsulinism (62±21 years, M±S.D., 27–88 years) were not treated by surgery: aged patients (n=10), patients with malignant unresectable insulinomas (n=6; locally invasive, n=1; multimetastatic, n=5), multiple insulinomas (n=2), diffuse beta cell pat...

ea0029p1629 | Thyroid (non-cancer) | ICEECE2012

Clinical presentation (symptoms and complications) of hyperthyroidism in a cohort of 1,144 patients: results of the Thyrdel study

Goichot B. , Bouee S. , Ndaye N. , Caron P. , Landron F.

Symptoms and physical signs are variable and non specific in hyperthyroidism (HT). We report the results of a large study conducted among 263 French endocrinologists. Each investigator was asked to include all consecutive patients seen for HT during the study period. For each patient, symptoms, physical signs, biological data and treatment were recorded. The endocrinologists included 1,144 patients with HT: 802 Grave’s disease (GD), 121 multinodular goitres (MNG), 112 iat...

ea0029p1668 | Thyroid (non-cancer) | ICEECE2012

Diagnosis and therapeutic practices of hyperthyroidism in france. results of a survey on 263 endocrinologists and 1214 patients (the thyrdel study)

Goichot B. , Caron P. , Bouee S. , Luca F. , Landron F.

There are considerable variations in diagnosis and therapeutical practices in hyperthyroidism (HT) between countries. Few of these differences rely on a scientific basis. we present the results of a study conducted among a representative sample of 263 French endocrinologists. All consecutive patients seen for HT during the study period were included. Symptoms, biological data and treatment were recorded. 1214 patients with hyperthyroidism were included, 1144 had an identified ...

ea0029p1432 | Pituitary Clinical | ICEECE2012

Decreased IGF1 levels and GH-resistant hepatic state to estrogens during the first trimester of pregnancy in non-acromegalic women

Persechini M. , Gennero I. , Grunenwald S. , Vezzosi D. , Bennet A. , Caron P.

Introduction: In women with GH-secreting pituitary adenoma, a decrease of IGF1 levels has been reported during the first trimester of pregnancy, before placental GH (pGH) secretion inducing a progressive increase in IGF1 levels throughout gestation. This decrease has been related to hepatic GH-resistant state, via JAK2/STAT pathway, due to increased estrogen (E2) levels.Objectives: Evaluate IGF1 change in non-acromegalic women during the first...

ea0029p1617 | Thyroid (non-cancer) | ICEECE2012

Subclinical hyperthyroidism (SH) in the elderly: symptoms, depression and quality of life (QoL) and relationship with TSH concentration in a prospective cohort of 110 patients

Goichot B. , Vinzio S. , Kuhn J. , Meyer N. , Wemeau J. , Caron P. , Luca F. , Orgiazzi J.

SH is defined by a decrease of TSH with normal thyroid hormone (TH) concentrations. The clinical picture is not clear, whether these patients may have symptoms or alterations of QoL. It is well known that in overt hyperthyroidism, symptoms may be absent in old patients. In SH, one study in young patients has reported an increased symptom score and a slight decrease of QoL but these results have not been confirmed in middle-aged subjects. We report the initial data of the Pirat...

ea0011p774 | Thyroid | ECE2006

The reference ranges of maternal thyroid hormon (thyrotropin and free thyroxin) at the second and third trimesters of pregnancy: impact of FT4 assays

d’Herbomez M , Forzy G , Sapin R , Houze de l’Aulnoit D , Lepers S , Caron P

The aim of our study was to evaluate the reference ranges of thyrotropin (TSH) and free thyroxin (FT4) assayed with 5 methods at the second and the third trimesters of pregnancy for women with iodine intake at the lower limit of the normal range. This study used 297 sera (42 controls without pregnancy with age <40 years, 139 women at the second trimester and 116 at the third with mean age to 27 years in both groups). The assays were for TSH (Elecsys Roche), for thyroproxid...

ea0011oc20 | Clinical endocrinology | ECE2006

A European prospective real-life observational study of Quality of Life in patients with acromegaly

Webb SM , Colao A , Caron P , Carvalheiro M , Ertürk E , Pokrajac-Simeunovic A , Schopohl J , Tsagarakis S , Pearson IV , Badia X , Caglio S , Vincenzi B

The primary aim of this study, the largest European, single evaluation, observational trial to date, was to evaluate the impact of acromegaly on health-related quality of life (HRQoL) in patients with biochemically documented active disease, receiving Sandostatin® LAR® at a dose prescribed by their physician for at least 3 months. Secondary objectives were to investigate the relationships between HRQoL and subpopulations based on exploratory var...

ea0029oc13.3 | Adrenal Basic | ICEECE2012

Cortisol secretion is dependent on intraadrenal production of ACTH in macronodular bilateral adrenal hyperplasia causing Cushings syndrome

Louiset E. , Duparc C. , Young J. , Boutelet I. , Renouf S. , Bram Z. , Groussin L. , Caron P. , Tabarin A. , Grunenberger F. , Christin-Maitre S. , Kuhn J. , Anouar Y. , Bertherat J. , Lefebvre H.

Illicit expression of membrane receptors for circulating regulatory factors, such as gastric inhibitory polypeptide (GIP), luteinizing hormone (LH) and serotonin (5-HT) receptors, has been well documented in ACTH-independent macronodular adrenal hyperplasias (AIMAHs) causing Cushing’s syndrome. In addition, we have observed an abnormal expression of ACTH in some steroidogenic cells in two AIMAH tissues. The aim of the present study was to investigate the role of local pro...

ea0029p993 | Growth hormone IGF axis - basic | ICEECE2012

Clinical characteristics and outcome of acromegaly induced by ectopic secretion of GHRH: a French nationwide series of 21 cases

Garby L. , Caron P. , Claustrat F. , Chanson P. , Tabarin A. , Rohmer V. , Arnault G. , Bonnet F. , Chabre O. , Christin Maitre S. , Du Boullay H. , Murat A. , Nakib I. , Sadoul J. , Sassolas G. , Claustrat B. , Raverot G. , Borson Chazot F.

Context: Ectopic GHRH secretion is a rare cause of acromegaly described mainly in isolated case reports.Setting: From the registry of the sole laboratory performing plasma GHRH assays in France, we identified cases of ectopic GHRH secretion presenting with acromegaly between 1983 and 2008.Patients: In total, 21 patients aged 14–77 years, from 12 French hospitals. Median GHRH was 548 ng/l (270–9779)....